Summary
The concentrations of glucose, pyruvate and lactate were determined in the blood and lumbar CSF of 63 patients with neuromuscular disorders and 40 controls. The glucose/lactate and lactate/pyruvate ratios were also calculated, in addition to the cytoplasmic NADH/NAD+ (nicotinamide-adenine dinucleotide-H/nicotinamide-adenine dinucleotide) ratio in the brain. Remarkable deviations from control values were found not only in blood but also in the CSF of patients with different neuromuscular diseases, particularly in Duchenne muscular dystrophy and peroneal muscular atrophy, indicative of disturbance of the carbohydrate metabolism in the central nervous system.
Zusammenfassung
Die Konzentration von Glukose, Pyruvat und Laktat wurde im venösen Blut und lumbalen Liquor bei 63 Patienten mit neuromuskulären Erkrankungen und bei 40 Kontrollpatienten gemessen. Die Glukose/Laktat- und Laktat/Pyruvat-Quotienten, im weiteren der cerebrale cytoplasmatische NADH/NAD+-Quotient, wurden errechnet. Nicht nur im Blut, sondern auch im Liquor der neuromuskulären Patienten, u.a. bei Kranken mit Duchenne-Dystrophie und mit neuronaler peronealer Atrophie, konnten ausgeprägte Abweichungen von den Kontrollen gefunden werden. Diese weisen auf die Störung des Kohlenhydrat-Stoffwechsels im ZNS dieser Kranken hin.
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Mechler, F., Diószeghy, P., Csenkér, E. et al. Carbohydrate metabolites in the blood and CSF of patients with neuromuscular disorders. J Neurol 226, 111–118 (1981). https://doi.org/10.1007/BF00313438
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DOI: https://doi.org/10.1007/BF00313438