Summary
The surface morphology of inner hair cells in the cochlea of the mouse is fully developed at birth. At this time a regular pattern of elongated microvilli covers the surfaces of outer hair cells at all levels of the cochlea. The sensory hair on outer hair cells undergo a morphological maturation during the first days postnatally. A mature surface morphology is reached 5–7 days after birth. There are two gradients in hair cell maturation in the cochlea: (1) basal to apical, and (2) from inner hair cells to the 3rd row of outer hair cells. Polarization of sensory hairs on an outer hair cell, i.e. polar differentiation of the sensory hairs in the radial direction, occurs as a stepwise increase in length of those facing the stria vascularis.
Similar content being viewed by others
References
Alford BR, Ruben RJ (1963) Physiological, behavioural and anatomical correlates of the development of hearing in mouse. Ann Otol Rhinol Laryngol 72:237–247
Anniko M (1976) The cytocochleogram in atoxyl-treated guinea pigs. Acta Otolaryngol (Stockh) 82:70–81
Anniko M (1980) Embryogenesis of the inner ear. III. Formation of the tectorial membrane in vivo and in vitro. Anat Embryol 160:301–313
Anniko M (1983a) Early development and maturation of the spiral ganglion. Acta Otolaryngol. (Stockh). In press
Anniko M (1983b) Embryonic development of vestibular sense organs and their innervation. In: Development of auditory and vestibular systems, pp 375–423. Ed R Romand. Academic Press, New York
Anniko M, Bagger-Sjöbäck D (1982) Maturation of junctional complexes during embryonic and early post natal development of inner ear secretory epithelia. Am J Otolaryngol 3:242–253
Anniko M, Lundquist P-G (1980) Temporal bone morphology after systemic arterial perfusion or intralabyrinthine in situ immersion. I. Hair cells of the vestibular organs and the cochlea. Micron 11:73–83
Anniko M, Nordemar H (1980) Embryogenesis of the inner ear. IV. Post natal maturation of the secretory epithelia of the cochlea in correlation to the elemental composition in the endolymphatic space. Arch Oto-Rhino-Laryngol 229:281–288
Anniko M, Wróblewski R (1981) Elemental composition of the developing inner ear. Ann Otol Rhinol. Laryngol 90:25–32
Anniko M, Nordemar H, Van De Water TR (1979) Embryogenesis of the inner ear. I. Development and differentiation of the mammalian crista ampullaris in vivo and in vitro. Arch Oto-Rhino-Laryngol 224:285–299
Anniko M, Spångberg M-L, Schacht J (1981) Adenylate cyclase activity in the fetal and the early postnatal inner ear of the mouse. Hearing Res 4:11–22
Cohen GM, Fermin CD (1978) The development of hair cells in the embryonic chick's basilar papilla. Acta Otolaryngol (Stockh) 86:342–358
Ehret G (1976) Development of absolute auditory thresholds in the house mouse (Mus musculus). J Am Audiol Soc 1:179–184
Fujimoto S, Yamamoto K, Hayabuchi I, Yoshizuka M (1981) Scanning and transmission electron microscope studies on the organ of Corti and stria vascularis in human fetal cochlear ducts. Arch Histol Jpn 44:223–235
Ham RG, Veomett MJ (1980) Mechanisms of development. The CV Mosby Company, USA
Hilding DA (1969) Electron microscopy of the developing hearing organ. Laryngoscope 79:1691–1704
Jahnke V, Lundquist P-G, Wersäll J (1969) Some morphological aspects of sound perception in birds. Acta Otolaryngol (Stockh) 67:581–592
Kikuchi K, Hilding D (1965) The development of the organ of Corti in the mouse. Acta Otolaryngol (Stockh) 60:207–219
Kraus H-J, Aulbach-Kraus K (1981) Morphological changes in the cochlea of the mouse after the onset of hearing. Hearing Res 4:89–102
Lenoir M, Shnersson A, Pujol R (1980) Cochlear receptor development in the rat with emphasis on synaptogenesis. Anat Embryol 160:253–262
Li CW (1978) Hair cell development in the inner ear. In: Ed O Johari. Scanning electron microscopy, vol II, pp 967–974. AMF O'Hare, Ill, SEM Inc, USA
Li CW, Ruben RJ (1979) Further study of the surface morphology of the embryonic mouse cochlear sensory epithelia. Otolaryngol Head Neck Surg 87:479–485
Mikaelian D, Ruben RJ (1965) Development of hearing in the normal CBA-J mouse. Acta Otolaryngol (Stockh) 59:451–461
Nordemar H (1983) Postnatal development of the vestibular sensory epithelium in the mouse. Acta Otolaryngol (Stockh) In press
Pujol R, Hilding D (1973) Anatomy and physiology of the onset of auditory function. Acta Otolaryngol (Stockh) 76:1–10
Rosenhall U (1971) Morphological patterns of the organ of Corti in birds. Arch Klin Exp Ohr-, Nas-u Kehlk-Heilk 200:42–51
Rubel EW (1978) Ontogeny of structure and function in the vertebrate auditory system. In: Ed M Jacobson. Handbook of sensory physiology, vol IX, pp 135–237. Springer, Berlin, Heidelberg, New York
Ruben RJ (1967) Development of the inner ear of the mouse. An autoradiographic study of terminal mitosis. Acta Otolaryngol (Stockh) Suppl 220:1–44
Schmidt RS, Fernandez C (1963) Development of mammalian endocochlear potentials. J Exp Zool 153:227–236
Sher AE (1971) The embryonic and postnatal development of the inner ear of the mouse. Acta Otolaryngol (Stockh). Suppl 285:1–77
Spoendlin H (1973) The innervation of the cochlear receptor. In: Ed AR Møller. Basic mechanisms in hearing, pp 185–234. Academic Press, New York
Van De Water TR, Ruben RJ (1973) Quantification of the in vitro development of the mouse embryo inner ear. Ann Otol Rhinol. Laryngol Suppl 4:19–21
Wersäll J, Flock Å, Lundquist P-G (1965) Structural basis for directional sensitivity in cochlear and vestibular sensory receptors. Cold Spring Harbor Symp Quart Biol 30:115–132
Wersäll J, Flock Å (1967) Morphological aspects on cochlear hair cell's physiology.0 In: Ed AB Graham. Sensorineural hearing processes and disorders. Little, Brown & Co. Boston, Mass, USA
Wessels NK (1977) Tissue interactions and development. Benjamin/Cummings, USA
Ylikoski J (1974) Correlative studies on the cochlear pathology and hearing loss in guinea pigs after intoxication with ototoxic antibiotics. Acta Otolaryngol (Stockh). Suppl 326:1–62
Author information
Authors and Affiliations
Additional information
Supported by grants from the Swedish Medical Research Council, project 12X-720, and the Foundation Tysta Skolan
Rights and permissions
About this article
Cite this article
Anniko, M. Postnatal maturation of cochlear sensory hairs in the mouse. Anat Embryol 166, 355–368 (1983). https://doi.org/10.1007/BF00305923
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00305923