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The major locus for multifactorial nonsyndromic cleft lip maps to mouse Chromosome 11

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Abstract

Cleft lip with or without cleft palate, CL(P), a common human birth defect, has a genetically complex etiology. An animal model with a similarly complex genetic basis is established in the A/WySn mouse strain, in which 20% of newborn have CL(P). Using a newly created congenic strain, AEJ.A, and SSLP markers, we have mapped a major CL(P)-causing gene derived from the A/WySn strain. This locus, here named clf1 (cleft lip) maps to Chromosome (Chr) 11 to a region having linkage homology with human 17q21-24, supporting reports of association of human CL(P) with the retinoic acid receptor alpha (RARA) locus.

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  1. Department of Medical Genetics, The University of British Columbia, 6174 University Boulevard, V6T 1Z3, Vancouver, British Columbia, Canada

    D. M. Juriloff & D. G. Mah

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  1. D. M. Juriloff
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Juriloff, D.M., Mah, D.G. The major locus for multifactorial nonsyndromic cleft lip maps to mouse Chromosome 11. Mammalian Genome 6, 63–69 (1995). https://doi.org/10.1007/BF00303246

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  • DOI: https://doi.org/10.1007/BF00303246

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