Summary
Commingling analysis of plasma uric acid levels in a random sample of 160 nuclear families supports the hypothesis that there is a mixture of three distributions. Assuming one, two, and three components in the underlying distribution, we obtained the corresponding p-values (for power transformation) as 0.059, 1.040, and 1.643, respectively. Path analysis with p=0.059 gives genetic (h 2) and cultural (c 2) heritabilities as 0.256 and 0.199, without much support for intergenerational differences, assortative mating, or maternal effects. Complex segregation analysis with p=0.059 supports multifactorial inheritance, consistent with the findings of Gulbrandsen et al. (1979) and Morton (1979) in other populations. This study also fails to support a major locus hypothesis, contrary to earlier reports.
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References
Fisher RA (1921) On the probable error of a coefficient of correlation deduced from a small sample. Metron 1:1–32
Gerrard J, Rao DC, Morton NE (1978) A genetic study of immunoglobulin E. Am J Hum Genet 30:46–58
Gulbrandsen CL, Morton NE, Rao DC, Rhoads GG, Kagan A (1979) Determinants of plasma uric acid. Hum Genet 50:307–312
Heiss G, Tamir I, Davis CE, Tyroler HA, Rifkind BM, Schonfeld G, Jacobs D, Frantz ID (1980) Lipoprotein-cholesterol distributions in selected North American populations: The Lipid Research Clinics Program Prelevance Study. Circulation 61:302–315
Lalouel JM, Morton NE (1982) Complex segregation analysis with pointers. Hum Hered 31:312–321
Maclean CJ, Morton NE, Elson RC, Lew S (1976) Skewness in commingled distributions. Biometrics 32:695–699
Morrison JA, Kelly KK, Mellies MJ, de Groot I, Glueck CJ (1978) Parent-child associations at upper and lower ranges of plasma cholesterol and triglyceride. Pediatrics 62:468–478
Morrison JA, Kelly KK, Horvitz R, Khoury P, Laskarzewski PM, Mellies MJ, Glueck CJ (1982) Parent-offspring and sibling lipid and lipoprotein associations during and after sharing of household environments: The Princeton School District Family Study. Metabolism 131:158–167
Morton NE (1979) Genetics of hyperuricemia in families with gout. Am J Med Genet 4:103–106
Morton NE, Maclean CJ (1974) Analysis of family resemblance. III. Complex segregation of quantitative results. Am J Hum Genet 26: 489–503
Morton NE, Gulbrandsen CL, Rhoads GG, Kagan A, Lew R (1978) Major loci for lipoprotein concentrations. Am J Hum Genet 30: 583–589
Morton NE, Rao DC, Lalouel JM (1982) Methods in genetic epidemiology. S Karger, New York (to be published)
Rao DC, Morton NE, Cloninger CR (1979a) Path analysis under generalized assortative mating. I. Theory. Genet Res 33:175–188
Rao DC, Morton NE, Gulbrandsen CL, Rhoads GG, Kagan A, Yee S (1979b) Cultural and biological determinants of lipoprotein concentrations. Ann Hum Genet 42:467–477
Rao DC, Laskarzewski PM, Morrison JA, Khoury P, Kelly K, Wette R, Russell J, Glueck CJ (1982) The Cincinnati Lipid Research Clinic Family Study: Cultural and biological determinants of lipids and lipoprotein concentrations. Am J Hum Genet (to be published)
Smyth CJ, Cotterman CW, Freyberg RH (1948) The genetics of gout and hyperuricemia—an analysis of nineteen families. J Clin Invest 27:749–759
Stecher RM, Hersh AH, Solomon WM (1949) The heredity of gout and its relationship to familial hyperuricemia. Ann Intern Med 31:595–614
Tyroler HA, Anderson T, Chase G, Ellis L, Mowery R, Valulick D (1979) The Lipid Research Clinics population Based Family Study. In: Sing C, Skolnick M (eds) Genetic analysis of common diseases: application to predictive factors in coronary disease. Alan R Liss, New York, pp 647–652
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This work was supported in part by N.I.H. and N.I.M.H. Grants GM 28719, and MH 31302, and by contract NO-1-HV-2-2914L from the National Heart, Lung, and blood Institute (Lipid Research Clinic's Program), General Clinical Research Center, and the CLINFO center Grant RR-00068-19
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Rao, D.C., Laskarzewski, P.M., Morrison, J.A. et al. The cincinnati lipid research clinic family study: Familial determinants of plasma uric acid. Hum Genet 60, 257–261 (1982). https://doi.org/10.1007/BF00303013
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DOI: https://doi.org/10.1007/BF00303013