Summary
Dopexamine hydrochloride, a dopamine analogue, has been reported, both experimentally and clinically, to increase renal blood flow (RBF) and improve renal function in normal kidneys. The availability of computer-enhanced radionuclide scintigraphy, which provides accurate non-invasive measurement of changes in RBF, enabled us to study the renographic effects of dopexamine hydrochloride in patients with chronic renal dysfunction (CRD). Ten patients suffering from CRD and ten normal kidney donors were the study population. Renography was performed, heart rate (HR) and blood pressure (BP) measured, and hematological and biochemical tests carried out before and after intravenous infusion of dopexamine 2 μg kg-1 min-1 for 60 min. The patient population displayed signficant increases in total cortical and medullary RBF and renographic clearance rate (CR), while in kidney donors the RBF was increased in all kidney regions with no change in CR. HR increased in both groups, while BP showed no significant changes. The hematological and biochemical changes were transient and returned to preinfusion levels after 24 h. It is concluded that dopexamine hydrochloride 2 μg kg-1 min-1 increases RBF and CR in patients with CRD.
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Anaise D, Sato K, Atkins HL, Bachvaroff R (1984) Scintigraphic evaluation of the viability of cold-preserved kidneys before transplantation. J Nucl Med 25:1304
Anaise D, Oster ZH, Atkins HL, Arnold AN, Weis S, Waltzer WC, Rapaport FT (1986) Cortex perfusion index: a sensitive detector of acute rejection crisis in transplanted kidneys. J Nucl Med 27:1697
Bass AS (1990) Contrasting effects of dopexamine hydrochloride on electrolyte excretion in the canine kidney. J Pharmacol Exp Ther 253:798
Baumann G, Felix SB, Filcek SAL (1990) Usefulness of dopexamine hydrochloride versus dobutamine in chronic congestive heart failure and effects on hemodynamics and urine output. Am J Cardiol 65:748
Bodenham AR, Park GR (1988) Dopexamine hydrochloride, a novel drug with renal vasodilator properties: two case studies. Intensive Care Med 14:663
Brown RA, Dixon J, Farmer JB, Hall JC, Humphries RG, Ince F, O'Connor SE, Simpson WT, Smith GW (1985) Dopexamine: a novel agonist at peripheral dopamine receptors and B2-adrenoceptors. Br J Pharmacol 85:599
Brown RA, Farmer JB, Hall JC, Humphries RG, O'Connor SE, Smith GW (1985) The effects of dopexamine on the cardiovascular system of the dog. Br J Pharmacol 85:609
Hilson AJW, Maisey MN, Brown CB, Ogg CS, Bewick MS (1978) Dynamic renal transplant imaging with Tc-99m DTPA (Sn) supplemented by a transplant perfusion index in the management of renal transplants. J Nucl Med 19:944
Hunter DN, Gray H, Mudaliar Y, Morgan C, Evans TW (1989) The effects of dopexamine hydrochloride on cardiopulmonary hemodynamics following cardiopulmonary bypass surgery. Int J Cardiol 23:365
Leier CV, Binkley PF, Carpenter J, Randolph PH, Unverferth DV (1988) Cardiovascular pharmacology of dopexamine in low output congestive heart failure. Am J Cardiol 62:94
Magrini F, Foulds R, Roberts N, Macchi G, Mondadori C, Zanchetti A (1988) Renal hemodynamic effects of dopexamine hydrochloride. Am J Cardiol 62:53c
Mousdale S, Clyburn PA, Mackie AM, Groves ND, Rosen M (1988) Comparison of the effects of dopamine, dobutamine and dopexamine upon renal blood flow: a study in normal healthy volunteers. Br J Clin Pharmacol 25:555
Piepsz A, Dobbeleir A, Erbsmann F (1977) Measurement of separate kidney clearance by means of 99mTc-DTPA complex and a scintillation camera. J Nucl Med 2:173
Rosa RM, Silva P, Young JB, Landsberg L, Brown RS, Rowe JW, Epstein FH (1980) Adrenergic modulation of extrarenal potassium disposal. N Engl J Med 302:431
Shabtai M, Anaise D, Miller F, Oster ZH, Atkins H, Waltzer WC, Yland MJ, Rapaport FT (1989) The predictive value of renal cortical perfusion indices during acute allograft rejection crises. Transplant Proc 21:1899
Smith GW, Naya I (1987) Inhibition of uptake-1 in the dog by dopexamine hydrocholoride. Br J Pharmacol 92:777
Ter Wee PM, Smith AJ, Rosman JB, Sluiter WJ, Donker AJM (1986) Effect of intravenous infusion of low-dose dopamine on renal function in normal individuals and in patients with renal disease. Am J Nephrol 6:42
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This study was carried out in the Urology and Nephrology Center, Mansoura, Egypt, and was partially supported by Fisons plc Pharmaceutical Division, Loughborough, UK.
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Atallah, M.M., Saied, M.M.A., El-Diasty, T.A. et al. Renal effect of dopexamine hydrochloride in patients with chronic renal dysfunction. Urol. Res. 20, 419–424 (1992). https://doi.org/10.1007/BF00294499
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DOI: https://doi.org/10.1007/BF00294499