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The reverse transforming effects of nerve growth factor on five human neurogenic tumor cell lines: in vitro results

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Summary

The role of nerve growth factor (NGF) in the development, maintenance and regeneration of the mammalian sensory and sympathetic nervous systems has been well characterized, as has the ability of NGF to induce a variety of neoplastic cell lines of nuroectodermal (neurogenic) origin to differentiate. The ability to stimulate neoplastic cells of neurogenic origin to differentiate suggests that NGF may prove useful as a reverse transforming agent for the treatment of neurogenic tumors. Five human neurogenic tumor cell lines were evaluated for their response to NGF in vitro to determine whether the NGF is capable of inducing changes consistent with a reverse transforming response. Results indicate that NGF was able to reverse some of the transformed properties of these tumor cell lines, as NGF treatment stimulated neoplastic cells to develop a more differentiated phenotype, diminished or arrested growth, and induced changes that were persistent.

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Author notes

  1. M. J. Yaeger

    Present address: Animal Disease Research and Diagnostic Laboratory, South Dakota State University, P.O. Box 2175, 57007, Brookings, SD, USA

Authors and Affiliations

  1. Department of Pathology, Michigan State University, 48824, East Lansing, MI, USA

    M. J. Yaeger, A. Koestner, K. Marushige & Y. Marushige

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  1. M. J. Yaeger
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  2. A. Koestner
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  3. K. Marushige
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  4. Y. Marushige
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Additional information

Supported by NIH grant CA32594, an NIH Post Doctoral Fellowship to Dr. Yaeger, a grant from the Preuss Foundation and a BRSG grant (College of Veterinary Medicine, Michigan State University)

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Yaeger, M.J., Koestner, A., Marushige, K. et al. The reverse transforming effects of nerve growth factor on five human neurogenic tumor cell lines: in vitro results. Acta Neuropathol 83, 72–80 (1991). https://doi.org/10.1007/BF00294433

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  • DOI: https://doi.org/10.1007/BF00294433

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