Abstract
The urinary excretion kinetics of p-nitrophenol were studied in rabbits following oral administration of parathion at a dose of 3 mg/kg. Elimination of p-nitrophenol began rapidly, and of the total amount excreted during the study period, 46% was excreted in the first 3 h; 85% was excreted at 6 h after administration of the pesticide. The mean maximum excretion rate of p-nitrophenol was 111.15±61.02 μg/h reached in a time of 0.77±0.26 h. The formation and disappearance rate constants of the metabolite were 2.85±2.80 h−1 and 0.80±0.28 h−1, respectively. A linear relationship was observed between the plasma concentrations of parathion and the urinary excretion rate of p-nitrophenol.
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References
Appleton HT, Nakatsugawa T (1977) The toxicological significance of paraoxon deethylation. Pestic Biochem Physiol 7: 451–465
Braeckman RA, Audenaert F, Willems JL, Belpaire FM, Bogaert MG (1983) Toxicokinetics of methyl parathion and parathion in the dog after intravenous and oral administration. Arch Toxicol 54: 71–82
Brown RD, Manno JE (1978) ESTRIP, a basic computer program for obtaining initial polyexponential parameter estimates. J Pharm Sci 67: 1687–1691
Chadwick RW, Copeland MF, Froehlich R, Cooke N, Whitehouse DA (1984) Interaction between γ-hexachlorocyclohexane and the gastrointestinal microflora and their effect on the absorption, biotransformation and excretion of parathion by the rat. J Agric Food Chem 32: 755–759
Davies JE, Enos HF, Barquet A, Morgade C, Danauskas JX (1979). Pesticide monitoring studies. The epidemiologic and toxicologic potential of urinary metabolites. Dev Toxicol Environ Sci 4: (Toxicol Occup Med) 369–378
Durham WF, Wolfe HR, Elliot JW (1972) Absorption and excretion of parathion by spraymen. Arch Environ Health 24: 381–387
Elliot JW, Walker KC, Penick AE, Durham WF (1960) A sensitive procedure for urinary p-nitrophenol determination as a measure of exposure to parathion. J Agric Food Chem 8: 111–113
Hayes WJ (1971) Studies on exposure during the use of anticholinesterase pesticides. Bull WHO 44: 277–288
Hayes GR, Funckes AJ, Hartwell WV (1964) Dermal exposure of human volunteers to parathion. Arch Environ Health 8: 829–833
Kuo T-L, Fong JM, Chen W-Y (1978) Studies on parathion poisoning. II. Urinary p-nitrophenol in acute parathion poisoning. J Formosan Med Assoc 77: 90–96
Michalke P (1982) Empfindcher nachweis von p-nitrophenol in blut und urin mit HPLC nach E 605 intoxikation. Z Rechtsmed 88: 195–202
Morgan DP, Hetzler HL, Slach EF, Lin LI (1977) Urinary excretion of paranitrophenol and alkyl phosphates following ingestion of methyl or ethyl parathion by human subjects. Arch Environ Contam Toxicol 6: 159–173
Neal RA (1967) Studies on the metabolism of diethyl 4-nitrophenyl phosphorothionate (parathion) in vitro. Biochem J 103: 183–191
Poore RE, Neal RA (1972) Evidence for extrahepatic metabolism of parathion. Toxicol Appl Pharmacol 23: 759–768
Peña-Egido MJ, Rivas-Gonzalo JC, Mariño-Hernandez EL (1988) Toxicokinetics of parathion in the rabbit. Arch Toxicol 61: 196–200
Roan CC, Morgan DP, Cook N, Paschal EH (1969) Blood cholinesterases, serum parathion concentrations and urine p-nitrophenol concentrations in exposed individuals. Bull Environ Contam Toxicol 4: 262–269
Sultatos LG, Minor LD (1986) Factors affecting the biotransformation of the pesticide parathion by the isolated perfused mouse liver. Drug Metab Dispos 14: 214–220
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Peña-Egido, M.J., Marino-Hernandez, E.L., Santos-Buelga, C. et al. Urinary excretion kinetics of p-nitrophenol following oral administration of parathion in the rabbit. Arch Toxicol 62, 351–354 (1988). https://doi.org/10.1007/BF00293622
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DOI: https://doi.org/10.1007/BF00293622