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Enzymuntersuchungen im Serum von schwachsinnigen Anstaltspatienten

Serum enzymes in hospitalized patients with mental deficiency

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Summary

A number of enzymes alkaline and acid phosphatase, lactic acid dehydrogenase, glutamic oxalacetate transaminase (GOT), aldolase, glucose-6-phosphat dehydrogenase (G-6-PD) in the serum of 81 patients with Langdon Down's syndrome and mental deficiency (idiocy) were investigated and then compared with a sample of 37 healthy persons. The enzyme activities were determined spectrophotometrically.

Statistically significant differences of alkaline and acid phosphatase, lactic acid dehydrogenase, and glutamic oxalacetate transaminase were demonstrated between oligophrenic patients and healthy persons; there was a distinct increase in the serum of patients. The values for aldolase and glucose-6-phosphat dehydrogenase were equal both in the serum of patients and of controls. There was no significant difference between the values of adult oligophrenics on one side and adult patients with Down's syndrome on the other. Until further notice children with serious mental deficiency — oligophrenics of unknown genesis as well as patients with Down's syndrome — demonstrated no definite evidence of enzymologically deviations compared with those of the control group.

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Authors and Affiliations

  1. Institut für Humangenetik der Universität Düsseldorf, Düsseldorf, Deutschland

    Friedrich Schweikhardt & Petar Grünwald

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  1. Friedrich Schweikhardt
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  2. Petar Grünwald
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(Direktor: Prof. Dr. med. H. Schade)

Nach einem am 22. 10. 1967 auf der 10. Tagung der Gesellschaft für Anthropologie und Humangenetik gehaltenen Vortrag.

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Schweikhardt, F., Grünwald, P. Enzymuntersuchungen im Serum von schwachsinnigen Anstaltspatienten. Hum Genet 5, 310–314 (1968). https://doi.org/10.1007/BF00291639

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  • DOI: https://doi.org/10.1007/BF00291639

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