Summary
9 patients with regular trisomic Down's syndrome, 3 female carriers from different t (DqGq) families and 2 carriers from the same t (21q22q) family were examined by quinacrine dihydrochloride fluorescence microscopy. A G group chromosome with a highly fluorescent band on its long arm was found in triplicate in all patients. The same chromosome was missing in the (DqGq) translocation carriers being involved in the translocation with a D chromosome. It was also missing in the (21q22q) carriers. This supports the suggestion that it is always the same chromosome which is involved in both regular and translocation Down's syndrome.
Quinacrine dihydrochloride is an easily available stain, which can be used for identification of human metaphase chromosomes.
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Mikkelsen, M. Identification of G group anomalies in Down's syndrome by quinacrine dihydrochloride fluorescence staining. Hum Genet 12, 67–73 (1971). https://doi.org/10.1007/BF00291036
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DOI: https://doi.org/10.1007/BF00291036