Abstract
One hundred and seventy-eight subjects, patients with Itai-itai disease and their family members, aged 12–87 years living in a cadmium (Cd)-polluted area in the Jinzu River basin (Cd-exposed group) and 176 controls (control group) were examined. In the Cd-exposed group urinary trehalase increased with increasing age, urinary β2-microglobulin (β2-m) and retinol-binding protein. Although urinary cadmium was higher in the Cd-exposed group, no particular correlation was found between urinary trehalase and urinary cadmium. Seventeen men and 11 women showed raised urinary trehalase activities despite normal values of urinary β2-m (<300 μg/g.creatinine), suggesting that urinary trehalase increases earlier than urinary β2-m. In 19 patients with Itai-itai disease included in the Cd-exposed group, urinary trehalase decreased with decreasing reciprocal of serum creatinine, suggesting that urinary trehalase decreases in the most advanced cases of chronic cadmium nephropathy due to reduced tubular cell mass.
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Bourbouze R, Baumann FC, Bonvalet JP, Farman N (1984) Distribution of N-acetyl-β-d-glucosaminidase along the rabbit nephron. Kidney Int 25: 636–642
Dance N, Price RG, Cattell WR, Lansdell J, Richards B (1970) The excretion of N-acetyl-β-d-glucosaminidase and β-galactosidase by patients with renal disease. Clin Chim Acta 27: 87–92
Ellis KJ, Morgan WD, Zanji I, Yasumura S, Vartsky D, Cohn SH (1981) Critical concentrations of cadmium in human renal cortex: Dose-effect studies in cadmium smelter workers. J Toxicol Environ Health 7: 691–703
Elinder CG, Edling C, Lindberg E, Kågedal B, Vesterberg O (1985) β2-microglobulinuria among workers previously exposed to cadmium: follow-up and dose-response analyses. Am J Ind Med 8: 553–564
Friberg L, Elinder CG, Kjellström T, Nordberg GF (1986) Cadmium and health: a toxicological and epidemiological appraisal. CRC Press, Florida
Iwata K, Katoh T, Kasuya M, Nakano M (1989) The optimum assay condition and normal value of urinary trehalase activity. Toxicol Lett (in press)
Kanai M, Sasaoka S, Naiki M (1972) Radioimmunoassay of retinol-binding protein and its use for an early detection of renal tubular disorders and differentiation of proteinuric patterns. Proc Symp Chem Physiol Pathol 12: 325–330 (in Japanese with English summary)
Katoh T, Aoshima K, Kubota Y, Tanaka M, Teranishi H and Kasuya M (1984) Simple pretreatment for the determination of heavy metals in blood and urine by flameless atomic absorption spectrophotometry: the application of low temperature plasma asher and chelate resin. Jpn J Hyg 39: 349 (in Japanese)
Kitagawa M (1986) Comparison of renal function tests with pathological findings of the kidney in autopsy cases with Itaiitai disease. Kankyo Hoken Report No. 52: 265–267 (in Japanese)
Kjellström T, Shiroishi K, Evrin PE (1977) Urinary β2-microglobulin excretion among people exposed to cadmium in the general environment. Environ Res 13: 318–344
Nakano M, Aoshima K, Teranishi H, Kasuya M (1986) Urinary trehalase activity and renal brush-border damage in inhabitants of a cadmium-polluted area (Jinzu River basin). Toxicol Lett 34: 159–166
Nakano M, Aoshima K, Katoh T, Teranishi H, Kasuya M, Katoh T (1987) Severity of tubular brush border damage in a cadmiumpolluted area (Jinzu River basin): clinical role of urinary trehalase. Environ Res 44: 161–168
Nishimura N, Oshima H, Nakano M (1986) Urinary trehalase as an early indicator of cadmium-induced renal tubular damage in rabbit. Arch Toxicol 59: 255–260
Nomiyama K, Sato C, Yamamoto A (1973) Early signs of cadmium intoxication in rabbits. Toxicol Appl Pharmacol 24: 625–635
Price RG (1982) Urinary enzymes, nephrotoxity and renal disease. Toxicology 23: 99–134
Raab WP (1972) Diagnostic value of urinary enzyme determinations. Clin Chem 18: 5–25
Roels HA, Lauwerys RR, Buchet GP, Bernard A, Chettle DR, Harvey TC, Al-Haddad IK (1981) In vivo measurement of liver and kidney cadmium in workers exposed to this metal: its significance with respect to cadmium in blood and urine. Environ Res 26: 217–240
Sacktor B (1968) Trehalase and the transport of glucose in the mammalian kidney and intestine. Proc Natl Acad Sci USA 60: 1007–1014
Schainuck LI, Striker GE, Culter RE, Benditt EP (1970) Structural-functional correlations in renal disease. Part II. The correlations. Hum Pathol: 631–641
Sudo T (1980) Immunochemical model for the agglutination reaction of Fr antigens in a new latex photometric immunoassay with near infrared turbidimetry. Kitasato Arch Exp Med 53: 55–68
Sugihira N and Saito H (1986) Urinary excretion of N-acetyl-β-d-glucosaminidase and β2-microglobulin in people living in a cadmium-polluted area. Jpn J Hyg 41: 665–671 (in Japanese with English summary)
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Iwata, K., Katoh, T., Morikawa, Y. et al. Urinary trehalase activity as an indicator of kidney injury due to environmental cadmium exposure. Arch Toxicol 62, 435–439 (1988). https://doi.org/10.1007/BF00288346
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DOI: https://doi.org/10.1007/BF00288346