Summary
When a DNA polymerase-deficient strain of E. coli (pol A- mutant; amber nonsense) was exposed to methyl methanesulfonate or to nitrosomethylurethan, drug-resistant mutants which had recovered the pol A+ character were isolated. On the other hand, exposure of pol A- bacteria to nalidixic acid or to streptozotocin resulted in the recovery of mutants with specific resistance only to nalidixic acid or streptozotocin. These mutants retained the pol A- character.
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D'Alisa, R.M., Carden, G.A., Carr, H.S. et al. “Reversion” of DNA polymerase-deficient Escherichia coli . Molec. Gen. Genet. 110, 23–26 (1971). https://doi.org/10.1007/BF00276041
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DOI: https://doi.org/10.1007/BF00276041