Summary
Among 70 human meningiomas cytogenetically investigated by us up till now, only 4 tumors showed a hyperdiploidy. 2 of them had a uniform stemline with 47 chromosomes (47,XX,G+ and 47, XY, C(?E)+); the other 2 meningiomas had a stemline with a modal number of 53 (55) chromosomes.
Zusammenfassung
Unter 70 menschlichen Meningiomen, die von uns bis jetzt untersucht worden sind, fanden sich lediglich 4 mit einem hyperdiploiden Chromosomensatz. 2 hatten eine einheitliche Stammlinie mit 47 Chromosomen (47, XX, G+ bzw. 47, XY, C(?E)+); die übrigen beiden Meningiome hatten Stammlinien mit einer sehr einheitlichen Modalzahl von 53 (55) Chromosomen.
Similar content being viewed by others
References
Goldberg, L. S., Winkelstein, A., Sparkes, R. S.: Acquired G-group trisomy in acute monomyeloblastic leukemia. Cancer 21, 613–618 (1968).
Grouchy, J. de, Nava, C. de: A chromosomal theory of Carcinogenesis. Ann. intern. Med. 69, 381–391 (1968).
Ilbery, P. L. T., Ahmad, A.: An extra small acrocentric chromosome in a case of acute monocytic leukemia. Med. J. Aust. 8, 330 (1965).
Kohn, G., Mellman, W. J., Moorhead, P.S., Loftus, J., Henle, G.: Involvement of C-group chromosomes in five Burkitt Lymphoma cell lines. J. nat. Cancer Inst. 38, 209–222 (1967).
Levan, A.: Non-random representation of chromosome types in human tumor stemlines. Hereditas (Lund) 55, 28–38 (1966).
Mark, J.: Two benign intracranial human tumours with an abnormal chromosomal picture. Acta neuropath. (Berl.) 14, 174–184 (1969).
Schmid, W., Vischer, D.: Spontaneous fragility of an abnormally wide secondary constriction region in a human chromosome no. 9. Humangenetik 7, 22–27 (1969).
Singer, H., Zang, K. D.: Cytologische und cytogenetische Untersuchungen an Hirntumoren. I. Die Chromosomenpathologie des menschlichen Meningioms. Humangenetik 9, 172–184 (1970).
Steenis, H. van: Chromosomes and cancer. Nature (Lond.) 209, 819–821 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zankl, H., Singer, H. & Zang, K.D. Cytological and cytogenetical studies on brain tumors. Hum Genet 11, 253–257 (1971). https://doi.org/10.1007/BF00274746
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00274746