Summary
Variation in mitochondrial DNA (mtDNA) in a sample of 110 Finns was analyzed with six restriction enzymes, AvaII, BamHI, HaeII, HinII, HpaI, and MspI, by using total blood cell DNA probed with mouse mtDNA. Two new enzyme morphs were observed, one for HaeII and one for HindII. Double-digestion experiments indicated that the BamHI morphs 2 and 3 result from base changes leading to AvaII morphs 3 and 9, respectively. Of the ten different mtDNA types observed, defined by restriction fragment patterns, seven have been previously described in Caucasoid populations. The three new “Finnish” mtDNA types can be derived from Caucasoid lineages by single restriction site changes. The results were used to reconstruct a phylogenetic tree for Caucasoid mtDNA types defined by the enzymes used. The frequencies of mtDNA types were used to compute genetic distances between Finns, Italians, and Israeli Jews. The frequencies of both enzyme morphs and mtDNA types show that the Finnish population is highly homogeneous.
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Anderson S, Bankier AT, Barrell BG, Brujin MHL de, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJH, Staden R, Young IG (1981) Sequence and organization of the human mitochondrial genome. Nature 290:457–465
Blane H, Chen K, D'Amore MA, Wallace DC (1983) Amino acid change associated with the major polymorphic HincII site of Oriental and Caucasian mitochondrial DNAs. Am J Hum Genet 35:167–176
Bonné-Tamir B, Johnson MJ, Natali A, Wallace DC, Cavalli-Sforza LL (1986) Human mitochondrial DNA types in two Israeli populations. A comparative study at the DNA level. Am J Hum Genet 38:341–351
Brega A, Gardella R, Semino O, Morpurgo G, Astaldi Ricotti GB, Wallace DC, Santachiara Benerecetti AS (1986a) Genetic studies on the Tharu population of Nepal: restriction endonuclease polymorphisms of mitochondrial DNA. Am J Hum Genet 39:502–512
Brega A, Scozzari R, Maccioni L, Iodice C, Wallace DC, Bianco I, Cao A, Santachiara Benerecetti AS (1986b) Mitochondrial DNA polymorphisms in Italy. I. Population data from Sardinia and Rome. Ann Hum Genet 50:327–338
Brown WM, Prager M, Wang A, Wilson AC (1982) Mitochondrial DNA sequences of primates: tempo and mode of evolution. J Mol Evol 18:225–239
Cann RL, Brown WM, Wilson AC (1984) polymorphic sites and the mechanisms of evolution in human mitochondrial DNA. Genetics 106:479–499
Cann RL, Stoneking M, Wilson AC (1987) Mitochondrial DNA and human evolution. Nature 325:31–36
Denaro M, Blanc H, Johnson MJ, Chen KH, Wilmsen E, Cavalli-Sforza LL, Wallace DC (1981) Ethnic variation in HpaI endonuclease cleavage patterns of human mitochondrial DNA. Proc Natl Acad Sci USA 78:5768–5772
Hauswirth WW, Laipis PJ (1985) Transmission genetics of mammalian mitochondria: a molecular model and experimental evidence. In: Quagliarello E, Slater EC, Palmieri F, Saccone C, Kroon AM (eds) Achievements and perspectives in mitochondrial research, vol 2: Biogenesis. Elsevier, New York Amsterdam, pp 49–60
Horai S, Matsunaga E (1986) Mitochondrial DNA polymorphism in Japanese. II. Analysis with restriction enzymes of four or five base pair recognition. Hum Genet 72:105–117
Horai S, Gojobori T, Matsunaga E (1984) Mitochondrial DNA polymorphsim in Japanese. I. Analysis with restriction enzymes of six base pair recognition. Hum Genet 68:324–332
Johnson MJ, Wallace DC, Gerris SD Rattazzi MC, Cavalli-Sforza LL (1983) Radiation of human mitochondrial DNA types analyzed by restriction endonuclease cleavage patterns. J Mol Evol 19:255–271
Nei M, Tajima F (1981) DNA polymorphism detectable by restriction endonucleases. Genetics 97:145–163
Nevanlinna HR (1972) The Finnish population structure. A genetic and genealogical study. Hereditas 71:195–236
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Vilkki, J., Savontaus, ML. & Nikoskelainen, E.K. Human mitochondrial DNA types in Finland. Hum Genet 80, 317–321 (1988). https://doi.org/10.1007/BF00273643
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DOI: https://doi.org/10.1007/BF00273643