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Electrophoretic variants of blood proteins in Japanese. IV. Prevalence and enzymologic characteristics of glucose-6-phosphate dehydrogenase variants in Hiroshima and Nagasaki

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Summary

Electrophoretic screening of glucose-6-phosphate dehydrogenase (EC 1.1.1.49, G6PD) was conducted one sample of 9,260 children born to the atomic bomb survivors in Hiroshima (Honshu) and Nagasaki (Kyushu). The prevalence of electrophoretic variants was 0.11% in males and 0.42% in females in Hiroshima, and 0.16% in males and 0.31% in females in Nagasaki. Enzymologic characteristics of 10 variants obtained from three males and seven hemizygous fathers of heterozygous females were examined. As a result, three new types of G6PD variants were identified among five variants detected in Hiroshima, and three new types among five variants in Nagasaki. All the variants except one belonged to Class 3, as defined by Yoshida et al. (1971).

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Author notes

  1. T. Kageoka

    Present address: Institute of Clinical Medicine, University of Tsukuba, Niihari-gun, 305, Ibaraki, Japan

  2. K. Goriki

    Present address: Department of Internal Medicine, Mihara Medical Association Hospital, 370-1, Miyaura-cho, 723, Mihara, Hiroshima, Japan

  3. S. Neriishi

    Present address: Department of Medicine, Radiation Effects Research Foundation, 8-6, 1-chome, Nakagawa, 850, Nagasaki, Japan

Authors and Affiliations

  1. Division of Biochemical Genetics, Department of Clinical Laboratories, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami Ward, 730, Hiroshima, Japan

    T. Kageoka, C. Satoh, K. Goriki, M. Fujita, S. Neriishi, K. Yamamura, J. Kaneko & N. Masunari

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  1. T. Kageoka
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  2. C. Satoh
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  3. K. Goriki
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  4. M. Fujita
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  6. K. Yamamura
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  7. J. Kaneko
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  8. N. Masunari
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Kageoka, T., Satoh, C., Goriki, K. et al. Electrophoretic variants of blood proteins in Japanese. IV. Prevalence and enzymologic characteristics of glucose-6-phosphate dehydrogenase variants in Hiroshima and Nagasaki. Hum Genet 70, 101–108 (1985). https://doi.org/10.1007/BF00273066

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  • DOI: https://doi.org/10.1007/BF00273066

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