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Synergistic antitumor activity of vincristine and VP-16-213

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  • Vincristine, VP-16-213
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Summary

The potential interaction of the antitumor agents vincristine and VP-16-213 was investigated in vivo. DBA/2 mice were inoculated with 106 P388 murine leukemia cells, after which single IP injections of saline only, vincristine only, VP-16-213 only, or a combination of vincristine and VP-16-213 were administered. Long-term survival (> 60 days) was observed in 0/45, 1/45 (2%), 9/135 (7%), and 44/135 (33%) mice, respectively (P<0.001). Treatment was most effective when VP-16-213 was administered 0–72 h after vincristine. A similar trend was observed in mice bearing P1534 murine leukemia. These data demonstrate synergistic antitumor activity between vincristine and VP-16-213 in a murine model.

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References

  1. Adamson RH, Dixon RL, Ben M, Crews L, Shohet SB, Rall DP (1965) Some pharmacologic properties of vincristine. Arch Int Pharmacodyn 157:299

    Google Scholar 

  2. Brownlee KA (1965) Statistical theory and methodology in science and engineering. Wiley, New York, p 163

    Google Scholar 

  3. Chiuten DF, Wodinsky I, Abraham D (1979) Influence of treatment schedule on the toxicity and antitumor activity of mitotic inhibitors and semisynthetic podophyllotoxin derivative. Am Soc Clin Oncol 20:402

    Google Scholar 

  4. Dombernowsky P, Nissen NI (1976) Combination chemotherapy with 4'demethylepipodophyllotoxin 9-(4,6-0-ethylidene-β-d-glucopyranoside), VP 16-213 (NSC 141540) in L1210 leukemia. Eur J Cancer 12:181

    Google Scholar 

  5. Hacker M, Roberts D, Jackson CW (1980) Effect of VM-26 on the hematological responses of mice to L1210 leukemia. Br J Cancer 42:697

    Google Scholar 

  6. Hollander M, Wolfe DA (1973) Nonparametric statistical methods. Wiley, New York, p 67

    Google Scholar 

  7. Jackson DV Jr, Bender RA (1978) The clinical pharmacology of the vinca alkaloids, epipodophyllotoxins, and maytansine. In: Pinedo HM (ed) Clinical pharmacology of anti-neoplastic drugs. Elsevier/North-Holland, Amsterdam, p 277

    Google Scholar 

  8. Momparler RL (1980) In vitro systems for evaluation of combination chemotherapy. Pharmacol Ther 8:21

    Google Scholar 

  9. Vogelzang NJ, Raghavan D, Kennedy BJ (1982) VP-16-213 (etoposide): The mandrake root from Issyk-Kul. Am J Med 72:136

    Google Scholar 

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Authors and Affiliations

  1. Oncology Research Center, Bowman Gray School of Medicine of Wake Forest University, 300 South Hawthorne Road, 27103, Winston-Salem, NC, USA

    Don V. Jackson Jr, Tony R. Long, Thomas F. Trahey & Timothy M. Morgan

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  1. Don V. Jackson Jr
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  2. Tony R. Long
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  3. Thomas F. Trahey
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  4. Timothy M. Morgan
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Jackson, D.V., Long, T.R., Trahey, T.F. et al. Synergistic antitumor activity of vincristine and VP-16-213. Cancer Chemother. Pharmacol. 13, 176–180 (1984). https://doi.org/10.1007/BF00269024

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  • DOI: https://doi.org/10.1007/BF00269024

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