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Synergistic interaction between UV and ionizing radiation in wild-type Schizosaccharomyces pombe

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Summary

A synergistic effect of combined UV and γ-ray exposure was observed for inactivation of wild-type Schizosaccharomyces pombe. A recombinational repair process, known to be important in restitution of damage induced by both radiations, appears to be involved; a radiation-sensitive mutant defective in this repair pathway showed essentially no synergistic interaction between UV and γ-rays.

Recovery from the synergistic effect of pre-exposure in wild-type cells did not display the expected fast γ-recovery and slow UV-recovery kinetics previously observed for regain of resistance to further exposure to the same radiation. Rather, UV-irradiated cells recovered quickly from synergistic inactivation on subsequent γ-exposure, while γ-irradiated cells recovered UV-resistance slowly. Recovery from synergism thus appears to reflect the nature of the second, and not the initial, radiation.

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Authors and Affiliations

  1. Biology and Health Physics Division, Atomic Energy of Canada Limited, Chalk River Nuclear Laboratories, KOJ IJO, Chalk River, Ontario, Canada

    Norman E. Gentner & Mary M. Werner

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  1. Norman E. Gentner
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  2. Mary M. Werner
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Communicated by Ch. Auerbach

AECL Reference No. 6154

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Gentner, N.E., Werner, M.M. Synergistic interaction between UV and ionizing radiation in wild-type Schizosaccharomyces pombe . Molec. Gen. Genet. 164, 31–37 (1978). https://doi.org/10.1007/BF00267595

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  • DOI: https://doi.org/10.1007/BF00267595

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