Abstract
Ventilation and perfusion SPECT images during tidal breathing were studied in 15 cases of lung cancer using 81mKr gas and 99mTc-microspheres. Furthermore, functional images of V/Q ratio and Q/V ratio were prepared, and their clinical significance is descussed with reference to general lung function. There was a decreas in %VC and %FEV 1.0in 7 of 15 cases, and an increase of AaDo2 in the blood gas analysis in 12 of 15 cases. Both planar and SPECT images showed ventilation and perfusion abnormalities in all 15 cases. Of these, 12 patients showed matched ventilation and perfusion defects, 2 patients a dead-space effect and 1 patient a shunt effect. In comparing planar and SPECT images, depiction of ventilation and perfusion impairments were equally clear in 11 cases, but in 3, showing a lobar or segmental defect with a shunt effect, the SPECT images were superior. In a patient with markedly impaired function of the affected lung, the remaining function could not be depicted by SPECT. From the above, it seems that better information can be obtained for understanding the ventilation and perfusion states of lung cancer by adding the SPECT images to the planar image.
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Evans RD (1968) Radiation Dosimetry 2nd ed. Academic Press, New York London, p 112
Fazio F, Pratt TA, McKenzie CG, Steiner RE (1979) Improvement in regional ventilation and perfusion after radiotherapy for unresectable carcinoma of the bronchus. Am J Roentgenol 133: 191–200
Kramer EL, Sanger JJ (1984) 81mKr gas and 99mTc-MAA V/Q ratio images for detection of V/Q mismatches. Eur J Nucl Med 9:345–350
Meignan M, Simonneau G, Oliveira L, Harf A, Cinotti L, Cavellier J-F, Duroux P, Ansquer J-C, Galle P (1984) Computation of ventilation-perfusion ratio with Kr-81m in pulmonary embolism. J Nucl Med 25:149–151
Narabayashi I, Otsuka N, (1984) Pulmonary ventilation and perfusion studies in lung cancer. Clin Nucl Med. 9:97–102
Rosen JM, Palestro CJ, Markowitz D, Alderson PO (1986) Significance of single ventilation/perfusion mismatches in Krypton-81m/Technetium-99m lung scintigraphy. J Nucl Med 27:361–365
Suematsu T, Narabayashi I (1985) Imaging diagnosis of gas exchange in patients with lung cancer: evaluation of regional ventilation and perfusion with functional imaging. Nippon Acta Radiol 25:630–640
Wernly JA, DeMeester TR, Kirchner PT, Myerowitz PD, Oxford FE, Golomb HM (1980) Clinical value of quantitative ventilation-perfusion lung scans in the surgical management of bronchogenic carcinoma. J Thorac Cardiovasc Surg 80:535–543
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Narabayshi, I., Suematsu, T. & Suematsu, C. Assessment of SPECT ventilation-perfusion imaging in patients with lung cancer. Eur J Nucl Med 12, 329–332 (1986). https://doi.org/10.1007/BF00263813
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DOI: https://doi.org/10.1007/BF00263813