Abstract
A method is described for measuring a number of parameters associated with an inorganic ion-exchange krypton generator. These are the activities of rubidium isotopes in inorganic ion-exchange krypton generators, the 81mKr extraction rate, the 81mKr activity delivered to patients during ventilation studies, the elution efficiency, and the radionuclide purity of the eluted gas. The method is based on the calibration of detectors, Ge(Li) and NaI(Tl), with a standardized 114mIn source at matching photon energies. The average activities present in our generators at the end of bombardment (EOB) were 14.6±3.8 mCi (81Rb), 6.2±1.6 mCi (82mRb) and 53±9.4 μCi (83Rb). The 81mKr extraction rate 2 h post-EOB was 10.2±2.3 mCi/min at an air flowrate of 1 l/min. The 81mKr activity delivered to patients during a ventilation study was 91±16 mCi. The elution efficiency of the generators averaged 50%±7% at an air flowrate of 1 l/min. The eluted gas contained Rb radioisotopic impurities in trace quantities of approximately 0.06 μCi/l.
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Acerbi E, Birattari C, Bonardi M, De Martinis C, Salomone A (1981) Kr(p,xn) Excitation functions and Rb-81/Kr-81m generator studies. Int J Appl Radiat Isot 32:465–479
Clark JC, Jones T, Macintosh A (1970) Kr-81m: an ultra-shortlived inert gas tracer for lung ventilation and perfusion studies with scintillation camera. Radioaktive Isotope in Klinik und Forschung, 444 (Urban and Schwarzenberg, München-Berlin-Wien)
Clark JC, Buckingham PD (1975) Short-lived radioactive gases for clinical use. Butterworths, London, pp 295–299
Clark JC, Horlock PL, Watson IA (1976) Krypton-81m generators. Radiochem Radional Lett 24:245–254
Colombetti LG, Mayron LW, Kaplan E, Barnes WE, Friedman AM, Gindler JE (1974) Continuous radionuclide generation. I. Production and evaluation of Kr-81m minigenerator. J Nucl Med 15:868–873
Courthamel CE (1970) Applied gamma-ray spectrometry. 2nd ed. Oxford Pergamon
Fremlin JH, Stammers K, Stewart FR (1978) A new generator for Krypton-81m. Nucl Instrum Methods 156:369–373
Homma Y, Kurata K (1979) Excitation functions for the production of Rb-81/Kr-81m via the 79Br(α,2n)81Rb and 81Br(3He,3n)81Rb reactions. Int J Appl Radiat Isot 30:345–348
Horiguchi T, Noma H, Yoshizowa Y, Hasai H, Kiso Y (1980) Excitation functions of proton-induced reactions on Rb-85. Int J Appl Rad Isot 31:141–151
Jones T, Clark JC, Hughes JM, Rosenzweig DY (1970) Kr-81m generator and its uses in cardiopulmonary studies with the scintillation camera. J Nucl Med 11:118–124
Koyama T, Koyama T, Hirokawa Y, Yoshizawa Y, Noma H, Horiguchi T, Kiso Y, Hasai H, Takemi H (1980) Kr-81m gas generator for lung ventilation study. Eur J Nucl Med 5:481–486
Lederer CM, Shirley VS (1978) Table of isotopes 7th ed. John Wiley and sons, New York
Mayron LW, Kaplan E, Colombetti LG, Friedman AM, Gindler JE (1975) A minigenerator for the production of Kr-81m and its applications. Int J Nucl Med Biol 2:40–42
Miller TR, Biello DR, Lee JI, Davis HH, Mattar AG, Ehrhardt GJ, Siegel BA (1981) Ventilation imaging with Kr-81m: A comparison with Xe-133. Eur J Nucl Med 6:11–16
Nosil J, Spaventi S, Slaus I (1977) Kr-81m: Production, application and use of computer for ventilation studies. Eur J Nucl Med 2:1–8
Ruth TJ, Lambrecht RM, Wolf AP, Thakur ML (1980) Cyclotron isotopes and radiopharmaceuticals: Aspects of production, elution and automation of Rb-81/Kr-81m generators. Int J Appl Radiat Isot 31:51–59
Vandecasteele C, Goethals C, Sambre J, Slegers G (1981) Routine production of 81Rb-81mKr generator using 82Kr(p,2n) 81Rb reaction. Radiochem Radioanal Lett 285:290
Yano Y, McRae Anger HO (1970) Lung function studies using short-lived Kr-81m and the scintillation camera. J Nucl Med 11:674–679
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Williams, N.R., Childs, P.O., Causer, D.A. et al. Measurements of the rubidium isotopic activities and the elution parameters of 81mKr generators using a standardized 114mIn source. Eur J Nucl Med 10, 33–38 (1985). https://doi.org/10.1007/BF00261760
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DOI: https://doi.org/10.1007/BF00261760