Skip to main content
SpringerLink
Log in

Urine composition in patients with urolithiasis during treatment with magnesium oxide

  • Originals
  • Published:
Urological Research Aims and scope Submit manuscript

Summary

Fifteen patients with recurrent renal stone formation were treated with 400 mg magnesium oxide daily. Urine composition was analyzed before the start of treatment and after 6–12 months. The urinary excretion of magnesium before and during treatment was 321±120 (mean ±SD) and 409±140 mmol per mol creatinine respectively, a difference that was not statistically significant. Urinary calcium increased from 473±186 to 662±213 mmol per mol creatinine (p<0.05). All patients who increased their excretion of magnesium also increased the urinary output of calcium and, as a result of this, the calcium/magnesium-quotients were unaffected by the treatment. No significant effect was observed on urine oxalate excretion. Serum concentrations of calcium, magnesium and urate all remained at the pre-treatment level. From the results obtained in this study, magnesium oxide in this dosage cannot be recommended for use in treatment of patients with urolithiasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Backman, U., Danielson, B. G., Johansson, G., Ljunghall, S., Wikström, B.: Magnesium metabolism in renal stone disease. Scandinavian Journal of Urology and Nephrology. Suppl. 51 (1979a)

  2. Backman, U., Danielson, B. G., Fellström, B., Johansson, G., Ljunghall, S., Wikström, B.: Biochemical and clinical effects of the prophylactic treatment of renal calcium stones with magnesium hydroxide. Scandinavian Journal of Urology and Nephrology. Suppl. 51 (1979b)

  3. Barilla, D. E., Notz, C., Kennedy, D., Pak, C. Y. C.: Renal oxalate excretion following oral oxalate loads in patients with ileal disease and with renal and absorptive hypercalciuria. American Journal of Medicine 64, 579 (1978)

    Google Scholar 

  4. Berg, von, W., Schneider, H.-J., Vogel, E.: Die Oxalatausscheidung im Harn bei oraler Oxalsäure- und Magnesiumzufuhr. Deutsche Zeitschrift für Verdauungs- und Stoffwechselkrankheiten 31, 241 (1975)

    Google Scholar 

  5. Evans, R. A., Forbes, M. A., Sutton, R. A. L., Watson, L.: Urinary excretion of calcium and magnesium in patients with calcium-containing renal stones. Lancet II, 958 (1967)

    Google Scholar 

  6. Fetner, C. D., Barilla, D. E., Townsend, J., Pak, C. Y. C.: Effects of magnesium oxide on the crystallization of calcium salts in urine in patients with recurrent nephrolithiasis. Journal of Urology 120, 399 (1978)

    Google Scholar 

  7. Hodgkinson, A.: Relations between oxalic acid, calcium, magnesium and creatinine excretion in normal men and male patients with calcium oxalate kidney stones. Clinical Science Molecular Medicine 46, 357 (1974)

    Google Scholar 

  8. Massry, S. G., Coburn, J. W.: The hormonal and non-hormonal control of renal excretion of calcium and magnesium. Nephron 10, 66 (1973)

    Google Scholar 

  9. Melnick, I., Landes, R. R., Hoffman, A. A., Burch, J. F.: Magnesium therapy for recurring calcium oxalate urinary calculi. Journal of Urology 105, 119 (1971)

    Google Scholar 

  10. Moore, C. A., Bunce, G. E.: Reduction in frequency of renal calculus formation by oral magnesium administration. A preliminary report. Investigative Urology 2, 7 (1964)

    Google Scholar 

  11. Pak, C. Y. C., Diller, E. C.: Ionic interaction with bone mineral. Effect of Mg2+, citrate3-, F- and SO 2-4 on the solubility, dissolution and growth of bone mineral. Calcified Tissue Research 4, 69 (1969)

    Google Scholar 

  12. Prien, E. L., Gershoff, S. N.: Magnesium oxide — pyridoxine therapy for recurrent calcium oxalate calculi. Journal of Urology 112, 509 (1974)

    Google Scholar 

  13. Takasaki, E.: Urinary magnesium and oxalic acid excretion in patients with recurrent oxalate urolithiasis. Investigative Urology 12, 251 (1975)

    Google Scholar 

  14. Tiselius, H.-G.: Excretion of 4-pyridoxic acid and oxalic acid in patients with urinary calculi. Investigative Urology 15, 5 (1977)

    Google Scholar 

  15. Tiselius, H.-G., Almgård, L. E., Larsson, L., Sörbo, B.: A biochemical basis for grouping of patients with urolithiasis. European Urology 4, 241 (1978)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, University Hospital, Linköping, Sweden

    Hans-Göran Tiselius & Christer Ahlstrand

  2. Department of Clinical Chemistry, University Hospital, Linköping, Sweden

    Lasse Larsson

Authors
  1. Hans-Göran Tiselius
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christer Ahlstrand
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lasse Larsson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tiselius, HG., Ahlstrand, C. & Larsson, L. Urine composition in patients with urolithiasis during treatment with magnesium oxide. Urol. Res. 8, 197–200 (1980). https://doi.org/10.1007/BF00256993

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00256993

Key words

Search

Navigation