Abstract
The pharmacokinetics, protein binding, excretion and tissue distribution of 67Ga after the administration of 67Ga-citrate to New Zealand White rabbits is described. Data for 67Ga blood levels were best described by an equation with three exponential components exhibiting half lives of 0.25 h, 7.4 h and 19.5 h, with almost all of the activity in a protein bound form. Weekly urinary excretion (∼ 27%), possibly in a metabolized form, and fecal elimination (∼20%) were greater than the reported values in man, but there was a similar organ distribution pattern in these animals as in man. The overall biological handling was judged to be similar in both species making the rabbit a suitable model for further 67Ga-citrate studies in vivo.
Article PDF
Similar content being viewed by others
References
Boxenbaum HG, Riegelman S, Elashoff RM (1974) Statistical estimates in pharmacokinetics. J Pharmacokinet Biopharm 2:123–148
Carmago EE, Wagner HN, Tsan MF (1979) Studies of gallium accumulation in inflammatory lesions: IV Kinetics of accumulation and the role of polymorphnuclear leukocytes in the distribution of gallium in experimental inflammatory exudates. Nuklearmedizin 18:147–150
Clausen J, Edeling CJ, Fogh J (1974) 67Ga binding to human serum proteins and tumor components. Cancer Res 34:1931–1937
Edwards CL, Hayes RL (1972) Localization of tumors with radio-isotopes. In: Gosowitz FA, Andrews GA, Viamonte M (eds) Clinical Uses of Radionuclides: Critical Comparison with Other Techniques. National Technical Information Service, Springfield, pp 618–639
Flatt RD, Carpenter AB (1971) Identification of crystalline material in urine of rabbits. Am J Vet Res 32:655–657
Gálle P (1981) Mechanism of renal concentration and elimination of indium and gallium: a study by nuclear tomography at the microscopic level. Eur J Nucl Med 6: A14
Hayes RL (1976) Factors affecting uptake of radioactive agents by tumor and other tissues. In: Tumor Localization with Radioactive Agents. IAEA, Vienna, pp 29–40
Hnatowich DL, Kulprathipanja S, Beh R (1977) The importance of pH and citrate concentration on the in vitro and in vivo behavior of radiogallium. Int J Appl Radiat Isot 28:925–931
Hoffer PB (1980a) Status of gallium-67 in tumor detection. J Nucl Med 21:394–398
Hoffer PB (1980b) Gallium and infection. J Nucl Med 21:484–487
Keller F, Maiga MK, Koeppe P (1983) 67Gallium kinetics in the blood of patients with malignant tumors. Nuklearmedizin 155–158
Larson SM (1978) Mechanisms of localization of gallium-67 in tumors. Semin Nucl Med 8:193–203
Larson SM (1981) Factors determining tumor affinity for gallium-67 citrate. In: Spencer RP (ed) Radiopharmaceuticals Structure-Activity Relationships. Grune and Stratton, Toronto, pp 167–181
Logan KJ, Ng PK, Turner CJ, Schmidt RP, Terner UK, Scott JR, Lentle BC, Noujaim AA (1981) Comparative pharmacokinetics of 67Ga and 59Fe in humans. Int J Nucl Med Biol 8:271–276
Metzler CM, Elfrina CM, McEwen AS (1974) A package of computer programs for pharmacokinetic modelling. Biometrics 30:562–563
Munn JI, Walters NH, Dudley HC (1951) Urinary excretion of gallium by man and animals. J Clin Lab Med 37:676–682
Nelson B, Hayes RI, Edwards CL, Knisely RM, Andrews GA (1972) Distribution of gallium in human tissues after intravenous administration. J Nucl Med 13:92–100
Scheffel U, Tsan MF (1980) Effect of serum unbound iron-binding capacity on the tissue distribution of 67Ga in abscess-bearing rabbits. Nucl Med 19:274–277
Sedman AJ, Wagner JG (1976) AUTOAN, A decision-making pharmacokinetic program. The Upjohn Centre for Clinical Pharmacology, University of Michigan Medical Centre, Ann Arbour, Michigan
van der Pompe WB (1979) Tumor imaging with non-specific substances. Thesis, University of Utrecht
Weisbroth SH, Flatt RE, Kraus AL (eds) (1974) The Biology of the Laboratory Rabbit. Academic Press, New York
Zivanovic MA, Taylor DM, McCready VR (1978) The chemical form of gallium-67 in urine. Int J Nucl Med Biol 5:97–100
Zivanovic MA, McCready VR, Taylor DM (1981) The urinary excretion of gallium-67 citrate in patients with neoplastic disease. Eur J Nucl Med 4:277–282
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sykes, T.R., Noujaim, A.A., Stephens-Newsham, L.G. et al. Biological behavior of 67Ga-citrate in New Zealand White rabbits. Eur J Nucl Med 13, 95–99 (1987). https://doi.org/10.1007/BF00256024
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00256024