Summary
In a 10-year prospective study of 241 people with ‘borderline diabetes” (impaired glucose tolerance) identified by screening of the Bedford adult population, 36 (15%) worsened to diabetes and 128 (53%) substantially improved their glucose tolerance. The major predictor of worsening to diabetes was the level of blood glucose at baseline. This was statistically significant (p < 0.05), independent of other factors, both for deterioration in the first and in the second five years of observation. Body mass index, a measure of adiposity, did not predict worsening to diabetes during the first five years, but was an independent and significant predictor of worsening during the second five years (p < 0.05). The apparent effect of adiposity was complex, for it was also significantly related to improvement in glucose tolerance during the 10-year follow-up. Persons with impaired glucose tolerance are a heterogeneous group and with present knowledge the ability to predict metabolic deterioration is limited.
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Sharp CL, Butterfield WJH, Keen H (1964) Diabetes survey in Bedford, 1962. Proc R Soc Med 57: 193–204
Jarrett RJ, Keen H, Boyns DR, Chlouverakis C, Fuller J (1969) The concomitants of raised blood sugar: studies in newly detected hyperglycaemics, 1. A comparative assessment of neurological functions in blood sugar groups. Guy's Hosp Rep 118: 237–246
Keen H, Chlouverakis C, Fuller J, Jarrett RJ (1969) The concomitants of raised blood sugar: studies in newly detected hyperglycaemics, 2. Urinary albumin excretion, blood pressure and their relation to blood sugar levels. Guy's Hosp Rep 118: 247–254
Armitage P (1971) Statistical methods in medical research. Blackwell, Oxford, pp 263–268
Walker SH, Duncan DB (1967) Estimation of the probability of an event as a function of several independent variables. Biometrika 54: 167–179
Jarrett RJ, Keen H, Fuller JH, McCartney M (1979) Worsening to diabetes in men with impaired glucose tolerance (“borderline diabetes”). Diabetologia 16: 25–30
O'Sullivan JB, Mahan CM (1965) Blood sugar levels, glycosuria, and body weight related to development of diabetes mellitus. J Am Med Assoc 194: 117–122
O'Sullivan JB, Mahan CM (1968) Prospective study of 352 young patients with chemical diabetes. N Engl J Med 278: 1038–1041
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Keen, H., Jarrett, R.J. & McCartney, P. The ten-year follow-up of the Bedford Survey (1962–1972): Glucose tolerance and diabetes. Diabetologia 22, 73–78 (1982). https://doi.org/10.1007/BF00254832
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DOI: https://doi.org/10.1007/BF00254832