Summary
The incidence and course of development of diabetes was studied for 12 months after subtotal pancreatectomy in five strains of rats. Operations were performed on 5–7-week old-male animals weighing 100–140 g, and, subsequently, rats with fasting blood glucose levels >8.3 mmol/l were considered to be diabetic. In Füllinsdorf Albino rats, the proportion of diabetic animals gradually increased during the course of the experiment to a maximum of 83%. In Holtzman and Piebald rats, the highest incidence (58% and 28% respectively) was observed 2–3 months after surgery, after which partial remission of their diabetes occurred. Spontaneously hypertensive rats completely recovered from an initially mild diabetic state within 6 months of the operation. In Lewis rats, only a small number of animals (15%) became diabetic towards the end of the experiment. The severity of diabetes also differed considerably between strains. The pancreatic insulin content in diabetic rats was 2%–7% and in operated non-diabetic rats 17%–26% of values in non-operated control animals of the same age and strain. However, in the operated non-diabetic rats, glucose tolerance and the insulin response to glucose were also impaired.
It is concluded that there are marked inter-strain differences in rats concerning the incidence and development of diabetes following subtotal pancreatectomy.
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Kaufmann, F., Rodriguez, R.R. Subtotal pancreatectomy in five different rat strains: Incidence and course of development of diabetes. Diabetologia 27, 38–43 (1984). https://doi.org/10.1007/BF00253499
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DOI: https://doi.org/10.1007/BF00253499