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A comparison between terminally radioiodinated hexadecenoic acid (125I-HA) and heptadecanoic acid (131I-H0A) in the dog heart

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Abstract

The regional myocardial distribution of 125I-16-iodo-9-hexadecenoic acid (125I-HA) and 131I-17-iodo-heptadecanoic acid (131I-H0A) was determined in one normal dog and in five dogs within 5 min after coronary artery occlusion. The total myocardial uptake of 125I-H A was about 40% lower than that of 131I-H0A. The ratio 125I:131I in the normally perfused parts of the myocardium was 0.38–0.81, but the ischemic tissue showed a higher 125I:131I-131I ratio (0.87–1.03), due to lower accumulation of 131I-H0A in ischemic myocardium. We conclude that both radioiodinated fatty acids are reliable indicators of myocardial perfusion and that iodo-heptadecanoic acid, when labeled with 123I, may be preferred to iodo-hexadecenoic acid as the labeled fatty acid for cardiac imaging agent in clinical practice.

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Authors and Affiliations

  1. Department of Cardiology, Free University Hospital, Amsterdam, The Netherlands

    E. E. van der Wall

  2. Department of Nuclear Medicine, Free University Hospital, Amsterdam, The Netherlands

    G. Westera, G. A. K. Heidendal & W. den Hollander

Authors
  1. E. E. van der Wall
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  2. G. Westera
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  3. G. A. K. Heidendal
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  4. W. den Hollander
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van der Wall, E.E., Westera, G., Heidendal, G.A.K. et al. A comparison between terminally radioiodinated hexadecenoic acid (125I-HA) and heptadecanoic acid (131I-H0A) in the dog heart. Eur J Nucl Med 6, 581–584 (1981). https://doi.org/10.1007/BF00252673

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  • DOI: https://doi.org/10.1007/BF00252673

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