Abstract
Lymphoscintigraphy with SC injection of 67Ga-citrate was carried out on patients with lymph node metastasis and malignant lymphoma. The dose given at each injection site was about 200 μCi and scintigraphy was started about 5 min after injection. Metastatic lymph nodes and malignant lymphoma were successfully imaged. This positive delineation corresponded well to cold lesions detected by lymphoscintigraphy with 99mTc-rhenium colloid in metastatic lymph nodes. Hotter lesions in malignant lymphoma were scanned positively with 99mTc-rhenium colloid by this method. In in vitro studies, incorporation of 67Ga-citrate in HeLa S3 cells was about 4 times that in macrophages, when the incubation time was 1 h, while colloidal uptake by macrophages was 13 times that by HeLa S3 cells. The binding of 67Ga to transferrin in lymph and pinocytosis are suggested mechanisms of localization. A combination of colloid-and sc 67Ga-lymphoscintigraphy would be of value in the diagnosis of lymph node disease.
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Ito, Y., Otsuka, N., Nagai, K. et al. Lymphoscintigraphy by SC injection of 67Ga-citrate. Eur J Nucl Med 7, 260–265 (1982). https://doi.org/10.1007/BF00251477
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DOI: https://doi.org/10.1007/BF00251477