Summary
Effect of dibutyryl cyclic adenosine 3′5′-monophosphate (dbcAMP) on mitotic activity in the thyroid of hypophysectomized rats has been examined. It has been demonstrated that dbcAMP stimulates the incidence of mitoses in the thyroid follicular cells. It is therefore suggested that cAMP may be a mediator of the proliferogenic effect of TSH on the thyroid in vivo. Cyclic AMP could also release some unidentified growth-promoting factors for the thyroid. A direct stimulating effect of dbcAMP on the proliferation of the thyroid follicular cells is assumed to be possible as well.
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References
Dumont JE (1971) The action of thyrotropin on thyroid metabolism. Vitam Horm 29:288–412
Gilman GA, Rall TW (1966) Studies on the relation of cyclic 3′5′-AMP CA to TSH action in beef thyroid slices. Fed Proc 25:617
Kippen AA, Loeb L (1935) The relation between the quantity of thyroid-stimulating hormone of the anterior pituitary gland administered and the proliferative activity and hypertrophy of the thyroid acini in guinea pigs. J Pharmacol Exp Therap 24:246–257
Pastan I, Katzen R (1967) Activation of adenyl cyclase in thyroid homogenates by thyroid-stimulating hormone. Biochem Biophys Res Commun 29:792–798
Pawlikowski M, Mróz-Wasilewska Z, Stepień H, Rychter J (1978) Cholinergic stimulation of the thyroid mitotic activity. Preliminary report. Endokrynol Pol 29:459–461
Pawlikowski M, Kunert-Radek J, Mróz-Wasilewska Z (1979) Biphasic inhibitory and stimulatory effects of thyrotropin on the mitotic activity of thyroid explants cultured in vitro. Endokrinologie 73:186–190
Pisarev MA, DeGroot LJ, Wilber JF (1970) Cyclic-AMP production of goiter. Endocrinology 87:339–342
Randle PJ (1979) Secretion mechanisms and insulin release. In: Pierluissi J (ed) Endocrine pancreas and diabetes. Excerpta Medica, Amsterdam Oxford, pp 47–63
See YP, Burrow GN, Liew CC (1979) Effect of thyrotropin on the phosphorylation of thyroid chromosomal proteins. Cand J Biochem 57:523–528
Turtle JR, Kipnis DM (1967) An adrenergic receptor mechanism for the control of cyclic 3′5′-adenosine monophosphate synthesis in tissues. Biochem Biophys Res Commun 28:792–802
Westermark B, Karlsson FA, Walinder O (1979) Thyrotropin is not a growth factor for human thyroid cells in culture. Proc Natl Acad Sci USA 76:2022–2026
Wilson B, Raghupathy E, Tonoue T, Tong W (1968) TSH-like actions of dibutyryl-cAMP on isolated bovine thyroid cells. Endocrinology 83:877–884
Winand RJ, Kohn LD (1975) Thyrotropin effects on thyroid cells in culture. J Biol Chem 250:6534–6540
Winand RJ, Wadeleux PA, Etienne-Decerf J, Kohn LD (1976) Biochemical basis of thyroid stimulation in using thyroid cells in tissue culture. In: Mühlen Avz, Scheusener H (eds) Biochemical basis of thyroid stimulation and thyroid hormone action. Georg Thieme Verlag, Stuttgart, pp 1–23
Zusman DR, Burrow GN (1975) Thyroid-stimulating hormone regulation of ornithine decarboxylase activity in the thyroid. Endocrinology 97:1089–1095
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Lewiński, A. Effect of dibutyryl cyclic adenosine 3′5′-monophosphate on mitotic activity in the thyroid of hypophysectomized rats. Cell Tissue Res. 211, 349–352 (1980). https://doi.org/10.1007/BF00236455
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DOI: https://doi.org/10.1007/BF00236455