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Functional in vivo interaction between growth hormone and dopamine systems are correlated to changes in striatal somatostatin levels as detected by voltammetry

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Abstract

The effects of growth hormone (GH) and somatomedin C (SmC), as well as those of apomorphine, dopamine (DA) agonist, or haloperidol (DA antagonist), upon the size of striatal voltammetric peaks 2 and 5 were investigated. Local intrastriatal injections of GH or SmC were followed by an increase in the height of both peak 2 (corresponding to the oxidation of extracellular dihydro-phenylacetic acid, DOPAC, a metabolite of DA) and peak 5 (which may represent the oxidation of striatal extracellular somatostatin, SRIF). Treatment with haloperidol also increased the size of the striatal catechol peak but was responsible for a reduction of the neuropeptidergic signal. By contrast, apomorphine determined a decrease in striatal peak 2 (DOPAC) while increasing the levels of peak 5 (SRIF). The data further support the chemical identification of peak 5 at +800 mV as related to the in vivo oxidation of SRIF; in addition they indicate the presence of a functional relationship between this neuropeptide and the GH and DA systems in the striatum of anaesthetised rats.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Q.M.C., Nottingham University, UK

    Francesco Crespi

  2. Istituto di Ricerche Farmacologiche M. Negri, via Eritrea 62, I-20157, Milan, Italy

    Francesco Crespi

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  1. Francesco Crespi
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Crespi, F. Functional in vivo interaction between growth hormone and dopamine systems are correlated to changes in striatal somatostatin levels as detected by voltammetry. Exp Brain Res 94, 363–370 (1993). https://doi.org/10.1007/BF00230196

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  • DOI: https://doi.org/10.1007/BF00230196

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