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Tuftsin induced tumor necrosis activity

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Abstract

Tuftsin induced tumor necrosis activity was investigated. The activity was found in mice serum several days after i.p. injection of tuftsin. Further experiments with adhering peritoneal and spleen cells indicated that macrophages were the source of the observed activity. The same effect was observed when promyelocytic leukemia cells (HL60) were stimulated with different concentrations of the peptide. These showed yet another possible mechanism for tuftsin antineoplastic activity.

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Authors and Affiliations

  1. Department of Virology, Institute of Biostructure, Medical Academy, 02004, Chalubinskiego 5, Warsaw, Massachusetts, Poland

    Marek S. Wleklik & Miroslaw Luczak

  2. Division of Protein Chemistry, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 02111, Boston, Massachusetts, USA

    Victor A. Najjar

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  1. Marek S. Wleklik
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  2. Miroslaw Luczak
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  3. Victor A. Najjar
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Wleklik, M.S., Luczak, M. & Najjar, V.A. Tuftsin induced tumor necrosis activity. Mol Cell Biochem 75, 169–174 (1987). https://doi.org/10.1007/BF00229905

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