Abstract
The increase of urinary albumin excretion has a predictive value for cardiovascular disease in insulin-dependent and non insulin-dependent diabetics. To study the relationship between urinary albumin excretion and serum lipids, 380 non insulin-dependent diabetics, 40 to 75 yr old, with urinary albumin excretion from 0 to 200 mg/l, and normal serum creatinine (less than 150 µmol/1), were surveyed. Urinary albumin excretion, was related positively to age (r2 = 0.014; p = 0.02), to systolic blood pressure (r2 = 0.073, p = 0.0001) and diastolic blood pressure (r2 = 0.052, p = 0.0001); a negative correlation existed with HDL-cholesterol (r2 = 0.043, p = 0.0001) and Apoprotein A1 (r2 = 0.044, p = 0.0001). A stepwise regression analysis was performed and resulted in three independently contributing variables related to urinary albumin excretion: First systolic blood pressure (F = 36), second Apoprotein A1 (F 24), third hemoglobin AlC (F = 6). The presence of hypertension or insulin therapy did not modify these findings. In conclusion, serum lipid seems an important determinant of urinary albumin excretion in non insulin-dependent diabetics.
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Abbreviations
- UAE:
-
Urinary Albumin Excretion
- IDDs:
-
Insulin-Dependent Diabetics
- NIDDs:
-
Non Insulin-Dependent Diabetics
- ACE:
-
Angiotensin-converting-enzyme
- HDL:
-
High Density Lipoproteins
- VLDL:
-
Very Low Density Lipoproteins
- LDL:
-
Low Density Lipoproteins
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Suraniti, S., Bled, F., Girault, A. et al. Serum lipids and urinary albumin excretion in non insulin-dependent diabetics. Mol Cell Biochem 109, 197–200 (1992). https://doi.org/10.1007/BF00229777
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DOI: https://doi.org/10.1007/BF00229777