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Medial vestibular nucleus in the guinea-pig: histaminergic receptors

I. An in vitro study

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Summary

Antihistaminergic drugs are currently used for the symptomatic treatment of vestibular related syndromes such as vertigo and motion sickness. We therefore investigated whether histamine could modulate the firing of medial vestibular nuclei neurones (MVNn). Recently, we have demonstrated that different cell types are present among MVNn in guinea-pig brainstem slices. Bath-application of histamine at 10-4 or 10-5 M induced a small membrane depolarization accompanied by a slight decrease in membrane resistance and a reversible increase in spontaneous firing in all MVN cell types. These effects were presumably postsynaptic as they persisted in a low calcium/high magnesium solution. Using a variety of agonists and antagonists of histamine receptors (H1, H2 and H3), we conclude that these effects are mediated by H2 receptors. The companion paper is concerned with an in vivo study of the histaminergic modulation of the vestibular function (Yabe et al., in press).

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References

  • Airaksinen MS, Panula P (1988) The histaminergic system in the guinea pig central nervous system: an immunocytochemical mapping study using an antiserum against histamine. J Comp Neurol 273: 163–186

    Google Scholar 

  • Arrang JM, Garbarg M, Schwartz JC (1983) Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature 302: 832–837

    Google Scholar 

  • Arrang JM, Garbarg M, Schwartz JC (1985) Autoregulation of histamine release in brain by presynaptic H3 receptors. Neuroscience 15: 553–562

    Google Scholar 

  • Arrang JM, Garbarg M, Lancelot JC, Lecomte JM, Pollard H, Robba M, Schunack W, Schwartz JC (1987a) Highly potent and selective ligands for histamine H3 receptors. Nature 327: 117–123

    Google Scholar 

  • Arrang JM, Garbarg M, Schwartz JC (1987b) Autoregulation of histamine synthesis in brain mediated by presynaptic H3 receptors. Neuroscience 23: 149–157

    Google Scholar 

  • Baldissera F, Broggi G, Mancia M (1967) Nystagmus induced by unilateral hemilabyrinthectomy affected by sleep-wakefulness cycle. Nature 215: 62–63

    Google Scholar 

  • Bouthenet ML, Ruat M, Sales N, Garbarg M, Schwartz JC (1988) A detailed mapping of histamine H1 receptors in guinea-pig central nervous system established by autoradiography with (I125) iodobolpyramine. Neuroscience 26: 553–600

    Google Scholar 

  • Brodal A (1984a) The vestibular nuclei in the macaque monkey. J Comp Neurol 227: 252–266

    Google Scholar 

  • Brodal A (1984b) Anatomy of the vestibular nuclei and their connections. In: Kornhuber HH (ed) Vestibular system. Part I. Basic mechanisms. Springer, Berlin Heidelberg, New York, pp 239–352

    Google Scholar 

  • Collins WE, Guedry FE (1962) Arousal effects and nystagmus during prolonged constant angular acceleration. Acta Otolaryngol (Stockh) 54: 349–363

    Google Scholar 

  • Collins WE, Crampton GH, Posner JB (1961) Effects of mental activity on vestibular nystagmus and the encephalogram. Nature 190: 194–195

    Google Scholar 

  • Douglas WW (1985) Histamine and 5-hydroxytryptamine (serotonin) and their antagonists. In: Gilman AG, Goodman LS, Rall TW, Murad F (eds) Pharmacological basis of therapeutics. Macmillan, London, pp 605–638

    Google Scholar 

  • Fisher AJEM (1991) Histamine in the treatment of vertigo. Acta Otolaryngol [Suppl] (Stockh) 479: 24–28

    Google Scholar 

  • Flandrin JM, Courjon JH, Jeannerod M, Schmid R (1979) Vestibulo-ocular responses during the states of sleep in the cat. Electroencephalogr Clin Neurophysiol 46: 521–530

    Google Scholar 

  • Grace AA, Llinás R (1985) Morphological artifacts induced in intracellularly stained neurons by dehydration: circumvention using rapid dimethyl sulfoxide clearing. Neuroscience 16: 461–475

    Google Scholar 

  • Greene RW, Haas HL (1990) Effects of histamine on dentate granule cells in vitro. Neuroscience 34: 299–303

    Google Scholar 

  • Haaksma EEJ, Leurs R, Timmerman H (1990) Histamine receptors: subclasses and specific ligands. Pharmacol Ther 47: 73–104

    Google Scholar 

  • Haas H, Konnerth A (1983) Histamine and noradrenaline decrease calcium-activated potassium conductance in hippocampal pyramidal cells. Nature 302: 432–434

    Google Scholar 

  • Haas HL, Greene RW (1986) Effects of histamine on hippocampal pyramidal cells of the rat in vitro. Exp Brain Res 62: 123–130

    Google Scholar 

  • Hauglie-Hanssen E (1968) Intrinsic neuronal organization of the vestibular nuclear complex in the cat. A Golgi study. Ergeb Anat Entwickl Gesch 40: 1–105

    Google Scholar 

  • Hill SJ (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol Rev 42: 45–83

    Google Scholar 

  • Hodes R, Suzuki JI (1965) Comparative thresholds of cortex, vestibular and reticular formation in wakefulness, sleep and rapid eye movement periods. Electroencephalogr Clin Neurophysiol 18: 239–248

    Google Scholar 

  • Hough LB (1988) Cellular localization and possible functions for brain histamine: recent progress. Prog Neurobiol 30: 469–505

    Google Scholar 

  • Kawabata A, Sasa M, Kishimoto T, Takaori S (1991) Effects of anti-vertigo drugs on medial vestibular nucleus neurons activated by horizontal rotation. Jpn J Pharmacol 55: 101–106

    Google Scholar 

  • Kirsten EB, Sharma JN (1976) Microiontophoresis of acetylcholine, histamine and their antagonists on neurons in the medial and lateral vestibular nuclei of the cat. Neuropharmacology 15: 743–753

    Google Scholar 

  • Lenzi GL, Pompeiano O, Satoh T (1968) Input-output relation of the vestibular system during sleep and wakefulness. Pflügers Arch 299: 326–333

    Google Scholar 

  • Lin JS, Sakai K, Jouvet M (1986) Role of hypothalamic histaminergic systems in the regulation of vigilance states in cats. C R Acad Sci [III] 303: 469–474

    Google Scholar 

  • Llinás R, Sugimori M (1980) Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J Physiol (Lond) 305: 171–195

    Google Scholar 

  • Mannen H (1965) Arborisations dendritiques. Etude topographique et quantitative dans le noyau vestibulaire du chat. Arch Ital Biol 103:197–219

    Google Scholar 

  • McCormick DA, Pape HC (1990) Noradrenergic and serotonergic modulation of a hyperpolarization-activated cation current in thalamic relay neurones. J Physiol (Lond) 431: 319–342

    Google Scholar 

  • Melvill Jones G, Sugie N (1972) Vestibulo-ocular responses in man during sleep. Electroencephalogr Clin Neurophysiol 32: 43–53

    Google Scholar 

  • Monnier M, Sauer R, Hatt AM (1970) The activating central effect of histamine on the central nervous system. Int Rev Neurobiol 12: 265–305

    Google Scholar 

  • Nicholson AN, Pasco PA, Stone BM (1985) Histaminergic system and sleep, studies in man with H1 and H2 antagonists. Neuropharmacology 24: 245–250

    Google Scholar 

  • Phelan KD, Nakamura J, Gallagher JP (1990) Histamine depolarizes rat medial vestibular nucleus neurons recorded intracellularly in vitro. Neurosci Lett 109: 287–292

    Google Scholar 

  • Pollard H, Schwartz JC (1987) Histamine neuronal pathways and their function. Trends neurosci 10: 86–89

    Google Scholar 

  • Precht W, Shimazu H (1965) Functional connections of tonic and kinetic vestibular neurons with primary vestibular afferents. J Neurophysiol 28: 1014–1028

    Google Scholar 

  • Raggenbass M, Dubois-Dauphin M, Charpak S, Dreifuss JJ (1987) Neurons in the dorsal motor nucleus of the vagus nerve are excited by oxytocin in the rat but not in the guinea pig. Proc Natl Acad Sci USA 84: 3926–3930

    Google Scholar 

  • Reding GR, Fernandez C (1968) Effects of vestibular stimulation during sleep. Electroencephalogr Clin Neurophysiol 24: 75–79

    Google Scholar 

  • Rössner W (1965) Stereotaktischer Hirnatlas vom Meerschweinchen. Pallas, Munich

    Google Scholar 

  • Ruat M, Traiffort E, Bouthenet ML, Schwartz JC, Hirschfeld J, Buschauer A, Schunack W (1990) Reversible and irreversible labeling and autoradiographic localization of the cerebral histamine H2 receptor using [125I]iodinated probes. Proc Natl Acad Sci USA 87: 1658–1662

    Google Scholar 

  • Sans A, Chat M (1976) Maturation postnatale des noyaux vestibulaires chez le chat: étude histologique par la méthode de GolgiCox. Brain Res 111: 13–30

    Google Scholar 

  • Satayavidad J, Kirsten EB (1977) Iontophoretic studies of histamine and histamine antagonists in the feline vestibular nuclei. Eur J Pharmacol 41: 17–26

    Google Scholar 

  • Schwartz JC, Arrang JM, Garbarg M, Pollard H, Ruat M (1991) Histaminergic transmission in the mammalian brain. Physiol Rev 71: 1–51

    Google Scholar 

  • Serafin M, Khateb A, Waele C de, Vibert N, Vidal PP, Mühlethaler M (1990a) In vitro and in vivo studies of the histaminergic receptors in the medial vestibular nuclei neurones of the guinea-pig. Soc Neurosci Abstr 16: 401.8

    Google Scholar 

  • Serafin M, Khateb A, Waele C de, Vidal PP, Mühlethaler M (1990b) Low threshold calcium spikes in medial vestibular nuclei neurones in vitro: a role in the generation of the vestibular nystagmus quick phase in vivo. Exp Brain Res 82: 187–190

    Google Scholar 

  • Serafin M, Waele C de, Khateb A, Vidal PP, Mühlethaler M (1991a) Medial vestibular nucleus in the guinea-pig. I. Intrinsic membrane properties in brainstem slices. Exp Brain Res 84: 417–425

    Google Scholar 

  • Serafin M, Waele C de, Khateb A, Vidal PP, Mühlethaler M (1991b) Medial vestibular nucleus in the guinea-pig. II. Ionic basis of the intrinsic membrane properties in brainstem slices. Exp Brain Res 84: 426–433

    Google Scholar 

  • Shimazu H, Precht W (1965) Tonic and kinetic responses of cat's vestibular neurons to horizontal angular acceleration. J Neurophysiol 28: 991–1013

    Google Scholar 

  • Steinbusch HWM (1991) Distribution of histaminergic neurons and fibers in rat brain. Comparison with noradrenergic and serotonergic innervation of the vestibular system. Acta Otolaryngol [Suppl] (Stockh) 479: 12–23

    Google Scholar 

  • Steinbusch HWM, Mulder AH (1985) Localization and projections of histamine immunoreactive neurons in the central nervous System of the rat. In: Ganellin CR, Schwartz JC (eds) Frontiers in histamine research. Plenum Press, Oxford, New York, pp 119–130

    Google Scholar 

  • Takeda N, Morita M, Kubo T, Yamatodani A, Watanabe T, Tohyama M, Wada H, Matsunaga T (1987) Histaminergic projection from the posterior hypothalamus to the medial vestibular nucleus of rats and its relation to motion sickness. In: Graham MD, Kemink JL (eds) The vestibular system: neurophysiologic and clinical research. Raven Press, New York, pp 601–617

    Google Scholar 

  • Tauber ES, Handelman G, Handelman R, Weitzman ED (1972) Vestibular stimulation during sleep in young adults. Arch Neurol 27: 221–228

    Google Scholar 

  • Von Bernuth H, Prechtl HFR (1969) Vestibulo-ocular response and its state dependency in newborn infants. Neuropediatrics 1:11–24

    Google Scholar 

  • Wada H, Inagaki N, Yamatodani A, Watanabe T (1991) Is the histaminergic neuron system a regulatory center for whole-brain activity? Trends Neurosci 14: 415–418

    Google Scholar 

  • Yabe T, Waele C de, Serafin M, Vibert N, Arrang JM, Mühlethaler M, Vidal PP (1992) Medial vestibular nucleus in the guinea-pig: histaminergic receptors. II. An in vivo study. Exp Brain Res

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Authors and Affiliations

  1. Département de Physiologie, CMU, 1 Rue Michel Servet, CH-1211, Geneva 4, Switzerland

    M. Serafin, A. Khateb & M. Mühlethaler

  2. Laboratoire de Physiologie Neurosensorielle CNRS, 15 Rue de l' Ecole de Médecine, F-75270, Paris Cedex 06, France

    N. Vibert & P. P. Vidal

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  1. M. Serafin
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  2. A. Khateb
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  3. N. Vibert
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  4. P. P. Vidal
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  5. M. Mühlethaler
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Serafin, M., Khateb, A., Vibert, N. et al. Medial vestibular nucleus in the guinea-pig: histaminergic receptors. Exp Brain Res 93, 242–248 (1993). https://doi.org/10.1007/BF00228391

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  • DOI: https://doi.org/10.1007/BF00228391

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