Skip to main content
SpringerLink
Log in

Chemical mechanism of insulin action via proteolytic formation of mediator peptides

  • Published:
Molecular and Cellular Biochemistry Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Larner, J., 1972. Diabetes 21: 428–438.

    Google Scholar 

  2. Larner, J., Takeda, Y., Brewer, G. B., Huang, L. C., Hazen, R., Brooker, G., Murad, F. & Roach, P., 1975. Metabolic Interconversion of Enzymes (Shaltiel, S., ed.) Springer-Verlag, pp. 71–85.

  3. Larner, J., Galasko, G., Cheng, K., DePaoli-Roach, A., Huang, L., Daggy, P. & Kellogg, J., 1979. Science 206: 1408–1410.

    Google Scholar 

  4. Jarett, L. & Seals, J. R., 1979. Science 206: 1406–1408.

    Google Scholar 

  5. Kiechle, F. L., Jarett, L., Popp, D. A. & Kotagal, N., 1980. Diabetes 29: 852–855.

    Google Scholar 

  6. Cheng, K., Galasko, G., Huang, L., Kellogg, J. & Larner J., 1980. J. Diabetes 29: 659–661.

    Google Scholar 

  7. Seals, J. R. & Czech, M. P., 1980. J. Biol. Chem. 255: 6529–6531.

    Google Scholar 

  8. Kikuchi, K., Schwartz, C., Creacy, S. & Larner, J., 1981. Molec. and Cell. Biochem. 37: 125–130.

    Google Scholar 

  9. Larner, J., Cheng, K., Schwartz, C., Kikuchi, K., Tamura, S., Creacy, S., Dubler, R., Galasko, G., Pullin, C. & Katz, M., 1981. FASEB Symp. Cellular Dynamics of Insulin Action. In Press.

  10. Seals, J. R. & Jarett, L., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 77–81.

    Google Scholar 

  11. Steck, T. L. & Dawson, G., 1974. J. Biol. Chem. 249: 2135–2142.

    Google Scholar 

  12. Schwartz, C. & Larner, J., 1981. Unpublished observations.

  13. Lawrence, J. C. Jr., Guinovart, J. J. & Larner, J., 1977. J. Biol. Chem. 252: 444–450.

    Google Scholar 

  14. Oron, Y. and Larner, J., 1980. Molec. and Cell. Biochem. 32: 153–160.

    Google Scholar 

  15. Lawrence, J. C. Jr. & Larner, J., 1978. J. Biol. Chem. 253: 2104–2113.

    Google Scholar 

  16. Kikuchi, K. & Larner, J., 1981. J. Biol. Chem. In press.

  17. Lawrence, J. C. Jr., Larner, J., Kahn, C. R. & Roth, J., 1978. Molec. and Cell. Biochem. 22: 153–157.

    Google Scholar 

  18. Goren, J. H., 1979. Diabetes 28: 391 (Abs. #188).

    Google Scholar 

  19. Kahn, C., Baird, K. L., Jarret, D. B. & Flier, J. S., 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 4209–4213.

    Google Scholar 

  20. Schlessinger, J., Schechter, Y., Willingham, M. C. & Pastan, I., 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 5353–5357.

    Google Scholar 

  21. DeLisi, C., 1981. Nature 289: 322–323.

    Google Scholar 

  22. Tarone, G., Hamasaki, N., Fukuda, M. & Marchesi, V. T., 1979. J. Memb. Biol. 48: 1–12.

    Google Scholar 

  23. Cullis, P. R. & DeKruijff, B., 1979. Biochim et Biophys. Acta 559: 399–420.

    Google Scholar 

  24. Robertson, R. N. & Thompson, T. E., 1977. FEBS Lett 76: 16–19.

    Google Scholar 

  25. Wolf, D. E., Schlessinger, J., Elson, E. L., Webb, W. W., Blumenthal, R. & Henkart, P., 1977. Biochemistry 16: 3476–3483.

    Google Scholar 

  26. Larner, J., Cheng, K., Galasko, G., Huang, L., Lawrence, J., Walkenbach, R. J., Roach, P. J. & DePaoli-Roach, A. A., 1981. The Regulation of Carbohydrate Formation and Utilization in Mammals (Veneziale, C. M., ed.) U. Park Press Baltimore, pp. 1–22.

  27. Hughes, R. C., 1975. Essays in Biochemistry 11: 1–36.

    Google Scholar 

  28. Czech, M., 1977. Ann. Rev. of Biochem. 46: 359–384.

    Google Scholar 

  29. Cushman, W. W. & Wardzala, L. J., 1980. J. Biol. Chem. 255: 4758–4762.

    Google Scholar 

  30. Suzuki, K., & Kono, T., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 2542–2545.

    Google Scholar 

  31. Zierler, K. & Rogus, E. M., 1981. Fed. Proc. 40, No. 2: 121–124.

    Google Scholar 

  32. Cheng, K., Groarke, J., Osotimekin, B., Haspel, H. C. & Sonenberg, M., 1981. J. Biol. Chem. 256: 649–655.

    Google Scholar 

  33. Zierler, K. & Rogers, E. M., 1980. Amer. J. Phys. 239: E21–29.

    Google Scholar 

  34. Carpentier, J. L., Gorden, P., Freychet, P., LeCam, A. & Orci, L., 1979. J. Clin. Invest. 63: 1249–1261.

    Google Scholar 

  35. Anderson, R. G. W., Goldstein, J.I. & Brown, M. S., 1980. J. Receptor Res. 1: 17–39.

    Google Scholar 

  36. Hofmann, C., Marsh, J. W., Miller, B. & Steiner, D. F., 1980. Diabetes 29: 865–874.

    Google Scholar 

  37. Livingston, J. N., Purvis, B. J. & Lockwood, D. H., 1978. Nature 273: 394–396.

    Google Scholar 

  38. Burger, M. M., 1970. Nature 227: 170–171.

    Google Scholar 

  39. Carney, D. H. & Cunningham, D. D., 1978. Cell. 14: 811–823.

    Google Scholar 

  40. Hayashi, I., Larner, J. & Sato, G., 1978. Cell. 14: 23–30.

    Google Scholar 

  41. Koontz, J. W., & Iwahashi, M., 1981. Science 211: 947–949.

    Google Scholar 

  42. Rieser, P., 1967. Insulin Membranes & Metabolism, Williams & Williams Co. Baltimore.

    Google Scholar 

  43. Steiner, D. F., Peterson, J. D., Tager, H., Endin, S., Ostberg, Y. & Falkmers, S., 1973. Amer. Zool. 13: 591–604.

    Google Scholar 

  44. DeHaen, C., Swanson, E. & Teller, D. C., 1976. J. Mol. Biol. 106: 639–661.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Pharmacology, University of Virginia School of Medicine Charlottesville, 22908, VA, USA

    J. Larner, K. Cheng, C. Schwartz, R. Dubler, S. Creacy, K. Kikuchi, S. Tamura, G. Galasko, C. Pullin & M. Katz

Authors
  1. J. Larner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Schwartz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Dubler
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Creacy
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. Kikuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S. Tamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. G. Galasko
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. C. Pullin
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M. Katz
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Established Investigator of the American Diabetes Association.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Larner, J., Cheng, K., Schwartz, C. et al. Chemical mechanism of insulin action via proteolytic formation of mediator peptides. Mol Cell Biochem 40, 155–161 (1981). https://doi.org/10.1007/BF00224609

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00224609

Keywords

Search

Navigation