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Estrogen dependent ciliogenesis in the chick oviduct

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Summary

Both the hormone dependency and the morphological details of estrogen-dependent ciliogenesis in the shell gland of the chick oviduct were investigated. Ciliogenesis was initiated on day 3 of estrogen treatment, and progressively more cells became differentiated until, on day 10, ∼ 55% ciliation occurred with 17β-estradiol (1 mg/day) and ∼75% ciliation occurred with diethylstilbestrol (1 mg/day). Simultaneous administration of progesterone with diethylstilbestrol (1 mg each/day for 10 days) caused a 50% depression in the number of ciliated cells on day 10. The rate of ciliogenesis was found to be affected by progesterone and the type of estrogen administered. The minimum stimulatory dose of estradiol was found to be between 0.01 mg/day and 0.05 mg/day. Ciliogenic cells were first recognized by the appearance of pro-basal bodies in the apical portion of the cell. Pro-basal body maturation and cilium formation were the same as those described for the chick trachea. Ciliogenesis in the chick was found to be homologous to estrogen-dependent ciliogenesis in various mammalian oviducts.

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Authors and Affiliations

  1. Department of Cell Biology, University of Texas, Health Science Center at Dallas, Dallas, Texas, USA

    Richard G. W. Anderson & Cheryl E. Hein

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  1. Richard G. W. Anderson
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  2. Cheryl E. Hein
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We would like to thank Dr. Frederick Grinnell for his helpful comments on the manuscript. This project was supported by a grant from the National Institutes of Health — HD 08987

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Anderson, R.G.W., Hein, C.E. Estrogen dependent ciliogenesis in the chick oviduct. Cell Tissue Res. 171, 459–466 (1976). https://doi.org/10.1007/BF00220238

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  • DOI: https://doi.org/10.1007/BF00220238

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