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Colocalization of the genes coding for the α3 and β3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3–q33

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Abstract

We have determined the chromosomal location of the human genes coding for the α3 and β3 subunits of soluble guanylyl cyclase (GC-S). The study was performed by in situ hybridization of human metaphase spreads with two human cDNA probes, containing the coding sequences of the GC-S α3 and β3 subunits, respectively. Each probe gave a strong specific signal on chromosome 4 at the 4q31.3–4q33 region, with the maximal signal in the 4q32 band. The colocalization of both genes in 4q32 represents an interesting feature for the coordinated regulation of expression of both GC-S subunits.

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Authors and Affiliations

  1. Institut National de la Santé et de la Recherche Médicale (INSERM), U-99, Hôpital Henri Mondor, F-94010, Créteil, France

    Galicia Giuili, Ute Scholl & Georges Guellaen

  2. Institut National de la Santé et de la Recherche Médicale (INSERM), U-242, Hôpital des Enfants de la Timone, F-13385, Marseille Cedex 5, France

    Nathalie Roechel & Marie-Geneviève Mattei

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  1. Galicia Giuili
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  2. Nathalie Roechel
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  3. Ute Scholl
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  4. Marie-Geneviève Mattei
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  5. Georges Guellaen
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Giuili, G., Roechel, N., Scholl, U. et al. Colocalization of the genes coding for the α3 and β3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3–q33. Hum Genet 91, 257–260 (1993). https://doi.org/10.1007/BF00218267

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  • DOI: https://doi.org/10.1007/BF00218267

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