Abstract
We describe a polymorphism in the 5′ region of the coagulation factor VII (FVII) gene, originating from a decanucleotide (CCTATATCCT) insert present in the less frequent allele. This marker can be detected by restriction analysis of polymerase chain reaction products.
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References
Marchetti G, Gemmati D, Patracchini P, Pinotti M, Bernardi F (1991) PCR detection of a repeat polymorphism within the F7 gene. Nucleic Acids Res 19:4570
Marchetti G, Patracchini P, Gemmati, DeRosa V, Pinotti M, Rodorigo G, Casonato A, Girolami A, Bernardi F (1992) Detection of two missense mutations and characterization of a repeat polymorphism in the factor VII gene (F7). Hum Genet 89:497–502
O'Hara PJ, Grant FJ, Haldeman BA, Gray CL, Insly MY, Hagen FS, Murray MJ (1987) Nucleotide sequence of the coding for human factor VII, a vitamin K-dependent protein participating in blood coagulation. Proc Natl Acad Sci USA 84:5158–5162
Pfeiffer RA, Ott R, Gilgenkrantz S, Alexandre P (1982) Deficiency of coagulation factors VII and X associated with deletion of a chromosome 13 (q34). Hum Genet 62:358–360
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Marchetti, G., Patracchini, P., Papacchini, M. et al. A polymorphism in the 5′ region of coagulation factor VII gene (F7) caused by an inserted decanucleotide. Hum Genet 90, 575–576 (1993). https://doi.org/10.1007/BF00217463
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DOI: https://doi.org/10.1007/BF00217463