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Predictors of mortality in very old subjects aged 80 years or over

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Abstract

We studied 318 subjects aged 80 years or over included in the Cardiovascular Study in the Elderly (CASTEL). Some well known risk factors (left ventricular hypertrophy, glucose intolerance, cholesterol, ApoB/ApoA ratio,. triglycerides, proteinuria, cigarette smoking, and ECG abnormalities), whose importance m cardiovascular risk is definitely accepted for young adults, were very poor predictors of mortality in our survey. On the contrary, FEV1 reduction and blood uric acid were strong predictors.

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References

  1. AgnerE. (1983): Predictive value of arterial blood pressure in old age - Acta Med. Scand. 214: 285–294.

    Google Scholar 

  2. AgnerE. and HansenP.F. (1983): Fasting serum cholesterol and triglycerides in a ten-year prospective study in old age - Acta Med. Scand. 214: 33–41.

    Google Scholar 

  3. BirkenhdgerW.H. and DeLeeuwP. W. (1988): Impact of systolic blood pressure on cardiovascular prognosis - J. of Hypertension 6 (Suppl. 1): 21–24.

    Google Scholar 

  4. CampbellA.J., BorrieM.J. and SpearsG.F. (1989): Risk factors for falls in a community-based prospective study of people 70 years and older - J. Gerontol. 44: M112–117.

    Google Scholar 

  5. CasaleP.N., DevereuxR.B., MilnerM., ZulloG., HarshfieldG.A., PickeringT.G. and LaraghJ.H. (1986): Value of echocardiographic measurement of left ventricular mass in predicting cardiovascular morbid events in hypertensive men - Ann. Intern. Med. 105: 173–178.

    Google Scholar 

  6. CasigliaE., SpolaoreP., MorminoP., Maschio0., ColangeliG., CelegonL., MaggioloG., TittotoL., PasinatoA. and AmbrosioG.B. (1991): The CASTEL (Cardiovascular Study in the Elderly): protocol, study design, and preliminary results of the initial survey -Cardiologia 36: 569–576.

    Google Scholar 

  7. CookN.R., EvansD.A., ScherrP.A., SpeizerF.E., TaylorJ.0. and Henne-kensC.H. (1991): Peak expiratory flow rate and 5-year mortality in an elderly population -Am. J. Epidemiol. 133: 784–794.

    Google Scholar 

  8. CooperS.P., HardyR.J., LabartheD.R., HawkinsC.M., SmithE.O.B., BlaufoxM.D., Cooper C.J., Entwisle G. and Maxwell M.H. (1988): The relation between degree of blood pressure reduction and mortality among hypertensives in Hypertension Detection and follow-up Program - Am. J. Epidemiol. 127: 387–402.

    Google Scholar 

  9. CruickshankJ.M., ThorpeJ.M. and ZachariasF.J. (1987): Benefits and potential harm of lowering high blood pressure - Lancet 1: 581–584.

    Google Scholar 

  10. De Baker G., RosseneuM. and DeslypereJ.P. (1982): Discriminative value of lipids and apoproteins in coronary heart disease - Atherosclerosis 42: 197–205.

    Google Scholar 

  11. DevereuxR.B.and ReichekN.(1972): Echo cardiographic determination of left ventricular mass in man. Anatomic evaluation of the method -Circulation 55: 613–618.

    Google Scholar 

  12. DuBoisD. and DuBoisF. (1916): A formula to estimate the approximative surface area if height and weight are known - Arch. Int. Med. 17: 863–871.

    Google Scholar 

  13. EkbomT., LindhomL., OdènA., DahlöfB., HanssonL., ScherstènB. and WesterP.O. (1988): Blood pressure does not predict mortality in the elderly - J. of Hypertension 6 (Suppl. 4): 626–628.

    Google Scholar 

  14. HammondI. W., DevereuxR.B., AldermanM.H., LutasE.M., SpitzerM.C., CrowleyJ.S. and LaraghJ.H. (1986): The prevalence and correlates of echocardiographic left ventricular hypertrophy among patients with uncomplicated hypertension - J. Am. Coll. Cardiol. 7: 639–643.

    Google Scholar 

  15. HarlanW.R., HullA.L., SchmouderR.L., LandisJ.R., LarkinF.A. and ThompsonF.E. (1984): High blood pressure in older Americans. The First National Health and Nutrition Examination Survey -Hypertension 6: 802–809.

    Google Scholar 

  16. KannelW., Gordon T. and SwartzM. (1971): Systolic vs diastolic blood pressure and risk of coronary disease - Am. J. Cardiol. 27: 335–346.

    Google Scholar 

  17. KannelW.B. and VokonasP.S.S. (1986): Primary risk factors for coronary heart disease in the elderly: The Framingham study. In: Coronary Heart Disease in the Elderly, Wenger N.K., Furberg C.P. and Pitt E. eds, Elsevier Science Publ., New York, p. 60–82.

    Google Scholar 

  18. LangerR.D., GaniatsT.G. and Barrett-ConnorE. (1989): Paradoxical survival of elderly men with high blood pressure - Br. Med. J. 298: 1356–1358.

    Google Scholar 

  19. LevineW., DyerA.R., ShekelleR.B., SchoenbergerJ.A. and StamlerJ. (1989): Serum uric acid and 11.5-year mortality of middle-aged women: findings of the Chicago Heart Association Detection Project in Industry - J. Clin. Epidemiol. 42: 257–267.

    Google Scholar 

  20. MacMahonS., PetoR., CutlerJ., CollinsR., SorliesP., NeatonJ., AbbottR., GodwinJ., PyerA. and StamlerJ. (1990): Blood pressure, stroke, and coronary heart disease. I. prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias - Lancet 335: 765–774.

    Google Scholar 

  21. MattilaK., HaavistoM., RajalaS. and HeikinheimoR. (1988): Blood pressure and five year survival in the very old - Br. Mod. J. 296: 887–889.

    Google Scholar 

  22. MausnerJ.S. and BalmA.K. (1974): Epidemiology. Saunders Co, Philadelphia, pp. 126–159.

    Google Scholar 

  23. McAnnultyJ.H., RahimtoolaS.H., MurphyE.S., KauffmanS., RitsmannL. W., KanarekP. and DeMotsH. (1978): A prospective study in “high risk” bundle branch block - N. Engl. J. Med. 299: 209–215.

    Google Scholar 

  24. NeatonJ.D., BlackburnH., JacobsD., KullerL., LeeD.J., Sherwin R., ShihJ., Stamler J. and WentworthD. (1992): Serum cholesterol level and mortality findings for men screened in the multiple risk factor intervention trial - Arch. Intern. Med. 152: 1490–1500.

    Google Scholar 

  25. OkadaM., VedaK., OmaeT., TakeshitaM. and HirotaY. (1982): The relationship of serum uric acid to hypertension and ischemic heart disease in Hisayama population, Japan - J. Chron. Dis. 35: 173–178.

    Google Scholar 

  26. RoseG.A., BlackburnH., GillumR.F. and PrineasR.J. (1982): Cardiovascular survey methods, Second edition, World Health Organization, Geneva, Switzerland.

    Google Scholar 

  27. SahnD.J., DeMariaA., KisslerJ. and WeymanA. (1978): The committee on M-mode standardisation of the American Society of Echocardiography: recommendations regarding quantification in M-mode echocardiography; results of a survey of echocardiographic measurement - Circulation 58: 1072–1080.

    Google Scholar 

  28. SchneiderJ.F., ThomasH.E., KregerB.E., McNamaraM., SorlieP. and KannelW.B. (1980): Newly acquired right bundle-branch block. The Framingham study -Ann. Intern. Med. 92: 37–44.

    Google Scholar 

  29. SelbyJ. V., FriedmanG.D. and QuesenberryC.P.Jr. (1990): Precursor of essential hypertension: pulmonary function, heart rate, uric acid, serum cholesterol, and other serum chemistries - Am. J. Epidemiol. 131: 1017–1027.

    Google Scholar 

  30. SmithG.D., ShipleyM.S., MarmotM.G. and RoseG. (1992): Plasma cholesterol concentration and mortality. The Withehall Study - JAMA 267: 70–76.

    Google Scholar 

  31. StronbergT.E., SalomaaV. V., NoukkainenV.A., VanhanenH.T., SamaS.J. and MietinenT.A. (1991): Long term mortality after 5-year multifactorial primary prevention of cardiovascular diseases in middle-aged men - JAMA 266: 1225–1229.

    Google Scholar 

  32. TeicholzL.E., KreulenT., HermanM. V. and GorlinR. (1976): Problems in echocardiographic volume determinations: echocardiographic and angiographic correlations in the presence or absence of asynergy -Am. J. Cardiol 37: 7–11.

    Google Scholar 

  33. TunickP.A., RobinS.F. and KronzonI. (1990): Cardiac findings in the very elderly: analysis of echocardiography in fifty-eight nonagerians -Gerontology 32: 206–211.

    Google Scholar 

  34. VokonasP.S., KannelW.B. and CupplesL.A. (1988): Epidemiology and risk of hypertension in the elderly: the Framingham Study - J. Hypertension. 6 (Suppl. 1): 3–9.

    Google Scholar 

  35. WallerP.C., IslesC. G., LeverA.F., MurrayG.D. and McInnesG.T. (1988): Does therapeutic reduction of diastolic blood pressure cause death from coronary heart disease? - J. Hum. Hypertens. 2: 7–10.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Clinical Medicine, University of Padova, Via Giustiniani, 2 - I-35126 Padova, Italy

    E. Casiglia, G. Ginocchio, G. Colangeli, G. Di Menza, M. Marchioro, A. Mazza & G. B. Ambrosio

  2. Hospital of Castefranco Veneto, Italy

    P. Spolaore

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  1. E. Casiglia
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  2. P. Spolaore
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  3. G. Ginocchio
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  4. G. Colangeli
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  5. G. Di Menza
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  6. M. Marchioro
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  7. A. Mazza
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  8. G. B. Ambrosio
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Casiglia, E., Spolaore, P., Ginocchio, G. et al. Predictors of mortality in very old subjects aged 80 years or over. Eur J Epidemiol 9, 577–586 (1993). https://doi.org/10.1007/BF00211430

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