Abstract
Numerous studies have demonstrated that several diseases and stress conditions are associated with changes in the levels of zinc in the blood plasma and cellular elements. In this research the association between serum zinc concentrations and other hematic parameters of diagnostic interest has been evaluated. Quantitative determinations of zinc, total plasmatic proteins, albumin, hemoglobin and calculation of mean corpuscular volume were performed on blood samples from 58 males aged 20–61 years. Concentrations measured in our sample are comparable with reference values. Statistically significant correlation coefficients were found between age and albumin (r = - 0.562, P < 0.001), serum zinc and albumin (r = 0.328, P < 0.05), serum zinc and hemoglobin (r = 0.291, P < 0.05), and total plasmatic proteins and albumin (r = 0.463, P < 0.001). These correlation coefficients were significant even after adjustment for age effect. The determination of serum zinc concentration may be useful in the assessment of clinical scenarios. Particularly, it may provide additional information for the diagnosis of specific pathologies, such as hepatic malfunctions. It could also be useful in the identification of different stages of anemia.
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References
Aggett PJ, Harries JT. 1979 Current status of zinc in health and disease states. Arch Dis Child 54, 909–917.
Burlina A, Bonessa C. 1981 Diagnostica di Laboratorio. Milano: Ferro Edizioni.
Butrimovitz GP, Purdy WC. 1977 The determination of zinc in blood plasma by atomic absorption spectrometry. Anal Chim Acta 94, 63–73.
Colloca A. 1989 Diagnostica di Laboratorio. Bologna: Editoriale Grasso.
Davidsohn I, Henry JB, eds. 1974 Clinical Diagnosis by Laboratory Methods, 15th edn. Philadelphia: WB Saunders.
Delves HT. 1987 Atomic absorption spectroscopy in clinical analysis. Ann Clin Biochem 24, 529–551.
Evans GW, Grace CI, Votava HJ. 1975 A proposed mechanism for zinc absorption in the rat. Am J Physiol 228 501–505.
Faure H, Favier A, Tripier M, Arnaud J. 1990 Determination of the major zinc fractions in human serum by ultrafiltration. Biol Trace Elem Res 24, 25–37.
Folin M, Contiero E, Vaselli GM. 1991 Trace elements determination in man: the use of blood and hair. Biol Trace Elem Res 31, 147–158.
Gilman JG, Brewer GJ. 1978 The oxygen-linked zincbinding site of human hemoglobin. Biochem J 169, 625–632.
Henry RJ, Cannon DC, Winkelman JW, eds. 1974 Clinical Chemistry. Principles and Techniques, II edn. Hagerstown: Harper & Row.
Kalfakakou V, Simons TJB. 1986 The mechanism of zinc uptake into human red blood cells. J Physiol 381, 75P.
Kritchevsky D. 1990 Nutritional requirements in aging. In: Goldstein AL, ed. Biomedical Advances in Aging. New York: Plenum Press.
Li T, Vallee BL. 1980 The biochemical and nutritional roles of other trace elements. In: Goodhart RS, Shils ME, eds. Modern Nutrition in Health and Disease. Philadelphia: Lea & Fabiger.
Natelson S, Natelson EA. 1980 Principles of Applied Clinical Chemistry, Vol. 3. Plasma Proteins in Nutrition and Transport. New York: Plenum Press.
Parisi AF, Vallee BL. 1970 Isolation of a zinc α 2-macroglobulin from human serum. Biochemistry 9, 2421–2426.
Peaston RT. 1973 Determination of copper and zinc in plasma and urine by atomic absorption spectrophotometry. Med Lab Technol 30, 249–253.
Prasad AS, Oberleas D. 1970 Binding of zinc to aminoacids and serum proteins in vitro. J Lab Clin Med 76, 416–425.
Prasad AS, Halsted AJ, Nadimi M. 1961 Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia. Am J Med 31, 532–546.
Prasad AS, Miale A, Farid Z, Sandstead HH, Schulert AR, Darby WJ. 1963a Zinc metabolism in patients with the syndrome of iron deficiency anaemia, hepato-splenomegaly, dwarfism and hypogonadism. J Lab Clin Med 61, 537–549.
Prasad AS, Miale A, Farid Z, Sandstead HH, Schulert AR, Darby WJ. 1963b Biochemical studies on dwarfism, hypogonadism and anaemia. Arch Intern Med 111, 407–428.
Smith JC, Butrimovitz GP. 1979 Direct measurement of zinc in plasma by atomic absorption spectroscopy. Clin Chem 25, 1487–1491.
Sokal RR, Rohlf FJ. 1981 Biometry, II edn. New York: WH Freeman.
Torrubia JOA, Garay R. 1989 Evidence for a major route for zinc uptake in human red blood cells: [Zn(HCO3)2Cl−] influx through the [Cl−/HCO3 −] anion exchanger. J Cell Physiol 138, 316–322.
Underwood EJ. 1977 Trace Elements in Human and Animal Nutrition, IV edn. New York: Academic Press.
Uza G, Vlaicu R. 1989 Serum zinc and copper in patients with atherosclerosis and thromboangiitis obliterans. Biol Trace Elem Res 20, 197–206.
Vallee BL, Gibson JG. 1948 Zinc content of normal human whole blood, plasma, leucocytes and erythrocytes. J Biol Chem 176, 445–457.
Van Wouwe JP, Veldhuizen M, De Goeij JJM, Van Den Hamer CJA. 1990 In vitro exchangeable erythrocytic zinc. Biol Trace Elem Res 25, 57–69.
Vir SC, Love AHG. 1979 Zinc and copper status of the elderly. Am J Clin Nutr 32, 1472–1476.
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Folin, M., Contiero, E. & Maria Vaselli, G. Zinc content of normal human serum and its correlation with some hematic parameters. Biometals 7, 75–79 (1994). https://doi.org/10.1007/BF00205198
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DOI: https://doi.org/10.1007/BF00205198