Summary
We coupled monoclonal IgMk antibodies directed against human breast carcinoma cells to the A-chain of the plant toxin ricin. These molecular hybrids maintain both their antibody-binding activity and the toxic activity of the A-chain. Thus, they specifically bind to and kill the breast carcinoma cells in vitro.
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Krolick, K.A., Yuan, D. & Vitetta, E.S. Specific killing of a human breast carcinoma cell line by a monoclonal antibody coupled to the A-chain of ricin. Cancer Immunol Immunother 12, 39–41 (1981). https://doi.org/10.1007/BF00200310
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DOI: https://doi.org/10.1007/BF00200310