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Treatment of carcinoma in situ of the bladder with BCG

A phase II trial

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Summary

Although carcinoma in situ conveys the idea of an early neoplasm, such lesions in the bladder mucosa commonly exhibit a very aggressive behavior and carry a grave prognosis. Seven patients with in situ carcinoma of the bladder have been treated with intravesical and systemic administration of Bacillus Calmette-Guérin. Elimination of tumor was documented by endoscopy, histology and cytology in five patients. These five patients have remained tumor-free for periods ranging between 12 and 33 months (mean: 22.6). This preliminary study indicates that regional and systemic immunotherapy is an alternative worth additional investigation in patients with carcinoma in situ of the bladder.

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References

  1. Althausen AF, Prout GR, Daly JJ (1976) Non-invasive papillary carcinoma of the bladder associated with carcinoma in situ. J Urol 116:575

    Google Scholar 

  2. Daly JJ (1976) Carcinoma in situ of the urothelium. Urol Clin North Am 3:87

    Google Scholar 

  3. Douville Y, Roy R, Charrois R, Kibrite A, Martin M, Dionne L, Coulonval L, Robinson J (1978) Recurrent bladder papillomata treated with BCG. A preliminary report. Cancer Treat Rep 62:661

  4. Eisenberg RB, Roth RB, Schweinsberg MH (1960) Bladder tumors and associated proliferative mucosal lesions. J Urol 84:544

    Google Scholar 

  5. Farrow GM, Utz DC, Rife CC (1977) Clinical observations on sixty-nine cases of in situ carcinoma of the urinary bladder. Cancer Res 37:2794

    Google Scholar 

  6. Melamed MR, Voutsa NG, Grabstald H (1964) Natural history and clinical behavior of in situ carcinoma of the human urinary bladder. Cancer 17:1533

    Google Scholar 

  7. Melicow MM (1952) Histological study of vesical urothelium intervening between gross neoplasms in total cystectomy. J Urol 68:261

    Google Scholar 

  8. Morales A, Eidinger D, Bruce AW (1976) Intracavitary Bacillus Calmette-Guérin in the treatment of superficial bladder tumors. J Urol 116:180

    CAS  PubMed  Google Scholar 

  9. Schade ROK, Swinney J (1973) The association urothelial atypism with neoplasia: its importance in treatment and prognosis. J Urol 109:619

    Google Scholar 

  10. Skinner DG, Richie JP, Cooper PH (1974) The clinical significance of carcinoma in situ of the bladder and it's association with overt carcinoma. J Urol 112:68

    Google Scholar 

  11. Utz DC, Hanash KD, Farrow GM (1970) The plight of the patient with carcinoma in situ of the bladder. J Urol 102:160

    Google Scholar 

  12. Whitmore WF, Jr, Phillips RF, Grabstald H (1963) Experience with pre-operative irradiation followed by radical cystectomy for treatment of bladder cancer. Am J Roentgenol 90:1016

    Google Scholar 

  13. Zbar B, Ribi E, Rapp HJ (1973) An experimental model for immunotherapy of cancer. Natl Cancer Inst Monogr 39:3

    Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Queen's University, K7L 2V7, Kingston, Ontario, Canada

    Alvaro Morales

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  1. Alvaro Morales
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Morales, A. Treatment of carcinoma in situ of the bladder with BCG. Cancer Immunol Immunother 9, 69–72 (1980). https://doi.org/10.1007/BF00199531

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  • DOI: https://doi.org/10.1007/BF00199531

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