Skip to main content
SpringerLink
Log in

The effect of Keyhole Limpet Hemocyanin (KLH) on the rat bladder

  • Short Communication
  • Published:
Cancer Immunology, Immunotherapy Aims and scope Submit manuscript

Summary

Immunostimulation with agents such as BCG or KLH may represent an adjuvant therapy in treating patients with bladder cancer. To investigate the effects of direct instillation and injection of KLH into the bladder of sensitized and nonsensitized rats, KLH was injected submucosally into the bladder. Histologically, a marked inflammatory reaction was seen without ulcerations.

KLH seems to give a more predictable reaction without the BCG side effects. Intralesional application of KLH, which is now in a clinical trial, may play a role in the treatment of bladder cancer after transurethral resection of the tumor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Bloomberg, S. D., Stanley, A., Brosman, M., Hausman, S., Cohen, A., Battenberg, J. D.: The effects of BCG on the dog bladder. Invest. Urol. 12, 423 (1975)

    Google Scholar 

  • Catalona, W. J., Chretien, P. B.: Correlation among host immuno-competence and tumor stage, tumor grade and vascular permeation in transitional carcinoma. J. Urol. (Baltimore) 110, 526 (1973)

    Google Scholar 

  • Klippel, K. F., Hutschenreiter, G.: Immunkompetenz bei Blasencarcinompatienten. Helv. chir. Acta 43, 267 (1976)

    Google Scholar 

  • Malley, A., Saha, A., Halliday, W. J.: Immunochemical studies of hemocyanin from the giant key-hole limpet. J. Immunol. 95, 141 (1965)

    Google Scholar 

  • Mathé, G.: Surviving in company of BCG. Cancer Immunol. Immunother. 1/2, 3 (1976)

    Google Scholar 

  • McLaughlin, A. P., III, Kessler, W. O., Triman, K., Gittes, R. F.: Immunologic competence in patients with urologic cancer. J. Urol. (Baltimore) 3, 233 (1974)

    Google Scholar 

  • Morton, D. L., Eilber, F. R., Holms, E. C., Hunt, J. S., Ketcham, A. S., Silverstein, M. J., Sparks, F. C.: BCG-immunotherapy of malignant melanoma. Ann. Surg. 180, 635 (1974)

    CAS  PubMed  Google Scholar 

  • Olsson, C. A., Chute, R., Chadalawa, N. R.: Immunologic reduction of bladder cancer recurrence rate. Trans. Amer. Ass. gen.-urin. Surg. 65, 66 (1973)

    Google Scholar 

  • Schwarzenberg, L., Simmler, M. C., Pico, J. L.: Human toxicology of BCG applied in cancer immunotherapy. Cancer Immunol. Immunother. 1, 69 (1976)

    Google Scholar 

  • Swanson, M. A., Schwartz, R. S.: Immunosuppressive therapy. New Engl. J. Med. 277, 163 (1967)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Urology and Pathology, University of Mainz, Medical School, Langenbeckstraße 1, D-6500, Mainz, Federal Republic of Germany

    K. F. Klippel, G. Paulini & G. Hutschenreiter

Authors
  1. K. F. Klippel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Paulini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Hutschenreiter
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Klippel, K.F., Paulini, G. & Hutschenreiter, G. The effect of Keyhole Limpet Hemocyanin (KLH) on the rat bladder. Cancer Immunol Immunother 3, 65–67 (1977). https://doi.org/10.1007/BF00199328

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00199328

Keywords

Search

Navigation