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Afferent connections of the nucleus centralis amygdalae

A horseradish peroxidase study and literature survey

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Summary

The central nucleus of the amygdala has been shown to be involved in cardiovascular regulation and the integration of arousal. In this study, the afferent input was investigated in cat by microinjecting horseradish peroxidase (HRP) into the central nucleus and examining retrogradely-labelled cells in the brain. Retrograde labelling was found in the cortex next to the sulcus ectosylvius anterior, fissura lateralis Sylvii, sulcus rhinicus anterior and posterior, sulcus suprasylvius, and pyriform and entorhinal cortices as well as in the insula and claustrum. Each of the sub-nuclei of the amygdaloid complex exhibited retrogradely-labelled perikarya. Labelled cells were also found in the diagonal band of Broca, nucl. lateralis septi, and nucl. proprius striae terminalis (bed nucl. of stria terminalis). In the hypothalamus the area preoptica medialis and lateralis, nucl. dorsomedialis, paraventricularis, periventricularis, arcuatus and mammilaris medialis were labelled. The nucl. subthalamicus, zona incerta, peripeduncular system, substantia nigra, and nucl. interpeduncularis contained HRP-marked cells. In the thalamus labelled cells were observed in the nucl. reuniens, nucl. centroposterior lateralis, nucl. latero-posterior, nucl. posterior, nucl. centro-anterior, antero-dorsalis, antero-medialis, antero-lateralis, centrum mdianum, nucl. reticularis, nucl. rhomboideus, nucl. parafascicularis and subfascicularis. The area tegmentalis Tsai and the corpora geniculata also contained labelled cells. In the brain stem, HRP-marked cells could be detected in the brachium colliculi inferioris, aqueductal grey matter, locus coeruleus, nucl. parabrachialis, in various nuclei of the formatio reticularis, in the nucl. retrofascialis, nucl. solitarius, nucl. commissuralis, nucl. ambiguus and nucl. dorsalis n. vagi. The results were compared to other neuroanatomical studies and to functional studies of the amygdala.

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Authors and Affiliations

  1. Department of Psychiatry, Free University of Berlin (West), Eschenallee 3, 19, Berlin, Federal Republic of Germany

    H. -P. Volz

  2. Institute of Physiology I, University of Heidelberg, Im Neuenheimer Feld 326, D-6900, Heidelberg, Federal Republic of Germany

    G. Rehbein & H. Stumpf

  3. Institute of Anatomy III, University of Heidelberg, Im Neuenheimer Feld 307, D-6900, Heidelberg, Federal Republic of Germany

    J. Triepel

  4. Department of Pharmacology, School of Medicine, 1402 South Grant Boulevard, 63104, St. Louis, MO, USA

    M. M. Knuepfer

  5. Research Laboratories of Schering AG, Institute of Pharmacology, D-1000, Berlin and Bergkamen, Federal Republic of Germany

    G. Stock

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  1. H. -P. Volz
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  2. G. Rehbein
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  4. M. M. Knuepfer
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  5. H. Stumpf
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Volz, H.P., Rehbein, G., Triepel, J. et al. Afferent connections of the nucleus centralis amygdalae. Anat Embryol 181, 177–194 (1990). https://doi.org/10.1007/BF00198957

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