Skip to main content
SpringerLink
Log in

The human aldose reductase gene maps to chromosome region 7q35

  • Original investigations
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

The human aldose reductase (AR) gene has been mapped to chromosome 7 using the polymerase chain reaction to specifically amplify the human AR sequence in hamster/human hybrid DNA and also in mouse/ human monochromosome hybrids. The assignment to chromosome 7 was confirmed by in situ hybridisation to human metaphase chromosomes using a novel, rapid hybridisation, method giving a regional localisation at 7q35.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Abbott C, West L, Povey S, Jeremiah S, Murad Z, DiScipio R, Fey G (1989) The gene for human complement component C9 mapped to chromosome 5 by polymerase chain reaction. Genomics 4:606–609

    Google Scholar 

  • Aghamahammadi SZ, Savage JRK (1989) A pulse BrdU method for SCE Mutat Res 216:259–266

    Google Scholar 

  • Anand R, Riley JH, Butler R, Smith JC, Markham AF (1990) A 3. 5 genome equivalent multi-access YAC library: construction, characterisation, screening and storage. Nucleic Acids Res 18:1951–1956

    Google Scholar 

  • Bohren KM, Bullock B, Wermuth B, Gabbay KH (1989) The aldo-keto reductase superfamily. J Biol Chem 264:9547–9551

    Google Scholar 

  • Chung S, La Mendola J (1989) Cloning and sequence determination of human placental aldose reductase gene. J Biol Chem 264:14775–14777

    Google Scholar 

  • Dean M, Park M, LeBeau MM, Robins TS, Diaz MO, Rowley JD, Blair DG, Van de Woude GF (1985) The human met oncogene is related to the tyrosine kinase oncogenes. Nature 318:385–388

    Google Scholar 

  • Dionne CA, Kaplan R, Seuanez H, O'Brien SJ, Jaye M (1990) Chromosome assignment by PCR techniques: assignment of the oncogene FGF-5 to human chromosome 4. Biotechniques 8:190–194

    Google Scholar 

  • Duncan AMV, Buchwald M, Tsui L-C (1988) In situ hybridisation of two cloned chromosome 7 sequences tightly linked to the cystic fibrosis locus. Cytogenet Cell Genet 49:309–310

    Google Scholar 

  • Elvin P, Slynn G, Black D, Graham A, Butler R, Riley JH, Anand R, Markham AF (1990) Isolation of cDNA clones using yeast artificial chromosome probes. Nucleic Acids Res 18:3913–3917

    Google Scholar 

  • Graham A, Hedge PJ, Powell SJ, Riley J, Brown L, Gammack AJ, Carey F, Markham AF (1989) Nucleotide sequence of cDNA for human aldose reductase. Nucleic Acids Res 17:8368

    Google Scholar 

  • Graham A, Brown L, Hedge PJ, Gammack AJ, Markham AF (1991) Structure of the human aldose reductase gene. J Biol Chem (in press)

  • Grundmann U, Bohn H, Obermeier R, Amann E (1990) Cloning and prokaryotic expression of a biologically active human placental aldose reductase. DNA Cell Biol 9:149–157

    Google Scholar 

  • ISCN (1985) An international system for human cytogenetic nomenclature. In: Harnden DG, Klinger HP (eds) Published in collaboration with Cytogenet Cell Genet. Kargel, Basel

    Google Scholar 

  • McNeill C, Brown R (1980) Genetic manipulation by means of microcell-mediated transfer of normal human chromosomes into recipient mouse cells. Proc Natl Acad Sci USA 77:5394–5398

    Google Scholar 

  • Riordan JR, Rommens JM, Kerem B, Alon N, Rozmahel R, Grzelczak Z, Zielenski J, Lok S, Plavsic N, Chou J-L, Drumm ML, Iannuzzi MC, Collins FS, Tsui L-C (1989) Identification of the cystic fibrosis gene: cloning and characterisation of complementary DNA. Science 245:1066–1073

    CAS  PubMed  Google Scholar 

  • Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, Arnheim N (1985) Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anaemia. Science 230:1350–1354

    CAS  PubMed  Google Scholar 

  • Saxon PJ, Srivatsan ES, Leipzig GV, Sameshima JG, Stanbridge EJ (1985) Selective transfer of individual human chromosomes to recipient cells. Mol Cell Biol 5:140–146

    Google Scholar 

  • Saxon PJ, Srivatsan ES, Stanbridge EJ (1986) Introduction of human chromosome 11 via microcell transfer controls tumorogenic expression of Hela cells. EMBO J 5:3461–3466

    Google Scholar 

  • Van Steeg H, Van Oostrom CTM, Martens JWM, Van Kreyl CF, Schepens J, Wieringa B (1989) Nucleotide sequence of the uman ornithine decarboxylase gene. Nucleic Acids Res 17:8855–8856

    Google Scholar 

  • Yang-Feng TL, Opdenakker G, Volckaert G, Francke U (1985) Mapping of the human tissue-type plasminogen activator (PLAT) gene to chromosome 8 (8p12–q11.2). Cytogenet Cell Genet 40:784

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biotechnology Department, ICI Pharmaceuticals, Alderley Park, SK10 4TG, Macclesfield, UK

    Alexander Graham, Paul Heath, John E. N. Morten & Alexander F. Markham

Authors
  1. Alexander Graham
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Paul Heath
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. John E. N. Morten
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alexander F. Markham
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Graham, A., Heath, P., Morten, J.E.N. et al. The human aldose reductase gene maps to chromosome region 7q35. Hum Genet 86, 509–514 (1991). https://doi.org/10.1007/BF00194644

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00194644

Keywords

Search

Navigation