Abstract
We report that high doses of the benzodiazepine derivative, clotiazepam, given in addition to standard neuroleptics often exert a minor beneficial effect on long-lasting, neuroleptic resistant auditory hallucinations in chronic schizophrenic patients of the residual type.
References
Lingjaerde O, Engstrand E, Ellingsen P, Stylo DA, Robak OH (1979) Antipsychotic effect of diazepam when given in addition to neuroleptics in chronic psychotic patients: a double-blind clinical trial. Curr Ther Res 26: 505–514
Beckmann H, Haas S (1980) High dose diazepam in schizophrenia. Psychopharmacology 71: 79–82
Lingjaerde O (1982) Effect of the bezodiazepine derivative estazolam in patients with auditory hallucinations. Acta Psychiatr Scand 65: 339–354
Nestoros JN, Nair NPV, Pulman JR, Schwartz G, Bloom D (1983) High doses of diazepam improve neuroleptic-resistant chronic schizophrenic patients. Psychopharmacology 81: 42–47
Jimerson DC, Van Kammen DP, Post RM, Docherty JP, Bunney WE (1982) Diazepam in schizophrenia: a preliminary double-blind trial. Am J Psychiatry 139: 489–491
Satow Y, Takazawa B (1986) Effect of high doses of neuroleptics and benzodiazepines on intractable hallucination and delusion in schizophrenia: preliminary open trial. Clin Psychiatry (Tokyo) 28: 203–211
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Jibiki, I., Yamaguchi, N. & Momonoi, F. Beneficial effect of high-dose clotiazepam on intractable auditory hallucinations in chronic schizophrenic patients. Eur J Clin Pharmacol 46, 367–369 (1994). https://doi.org/10.1007/BF00194407
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DOI: https://doi.org/10.1007/BF00194407