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References
Basta, V. P., Sherman, P. A., and Ting, J. P. Detailed delineation of an interferon-gamma-responsive element important in human HLA-DRA gene expression in a glioblastoma multiform line. Proc Natl Acad Sci USA 85: 8618–8622, 1988
Boss, J. M. and Strominger, J. L. Regulation of a transfected human class II major histocompatibility complex gene in human fibroblasts. Proc Natl Acad Sci USA 83: 9139–9142, 1986
Chin, K.-C., Mao, C., Skinner, C., Riley, J. L., Wright, K. L., Moreno, C. S., Stark, G. R., Boss, J. M., and Ting, J. P.-Y. Molecular analysis of G1B and G3A IFN-γ mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction. Immunity 1: 687–697, 1994
Dorn, A., Bollekens, J., Staub, A., Benoist, C., and Mathis, D. A multiplicity of CCAAT box-binding proteins. Cell 50: 863–872, 1987
Hasegawa, S. L. and Boss, J. M. Two distinct B cell factors bind the HLA-DRA X box region and recognize different subsets of MHC class II promoters. Nucleic Acids Res 19: 6269–6276, 1991
Hasegawa, S. L., Riley, J. L., Sloan, J. H., and Boss, J. M. Protease treatment of nuclear extracts distinguishes between class II major histocompatibility complex X1 box DNA-binding proteins in wild type and class II deficient B cells. J Immunol 150: 1781–1793, 1993
Herrero Sanchez, C., Reith, W., Silacci, P., and Mach, B. The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters. Mol Cell Biol 12: 4076–4083, 1992
Kern, M. J. and Woodward, J. G. The same CCAAT box-binding factor binds to the promoter of two coordinately regulated major histocompatibility complex class II genes. Mol Cell Biol 11: 578–581, 1991
Mach, B., Steimle, V., and Reith, W. MHC class II-deficient combined immunodeficiency: a disease of gene regulation. Immunol Rev 138: 207–221, 1994
Moreno, C. S., Emery, P., West, J. E., Durand, B., Reith, W., Mach, B., and Boss, J. M. Purified X2BP cooperatively binds the class II MHC X box region in the presence of purified RFX the X box factor deficient in the bare lymphocyte syndrome. J Immunol 155: 4313–4321, 1995
Reith, W., Satola, S., Herreo-Sanchez, C., Amaldi, I., Lisowska-Grospierre, B., Griscelli, C., Hadam, M. R., and Mach, B. Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X. Cell 53: 897–906, 1988
Reith, W., Kobr, M., Emery, P., Durand, B., Siegrist, C.-A., and Mach, B. Cooperative binding between factors RFX and X2bp to the X and X2 boxes of MHC class II promoters. J Biol Chem 269: 20020–20025, 1994a
Reith, W., Siegrist, C. A., Durand, B., Barras, E., and Mach, B. Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y. Proc Natl Acad Sci USA 91: 554–558, 1994b
Riley, J. L. and Boss, J. M. Class II MHC transcriptional mutants are defective in higher order complex formation. J Immunol 151: 6942–6953, 1993
Riley, J. L., Westerheide, S. D., Price, J. A., Brown, J. A., and Boss, J. M. Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA). Immunity 2: 533–543, 1995
Sloan, J. H., Hasegawa, S. L., and Boss, J. M. Single base pair substitutions within the HLA-DRA gen promoter separate the functions of the X1 and X2 boxes. J Immunol 148: 2591–2599, 1992
Steimle, V., Otten, L. A., Zufferey, M., and Mach, B. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell 75: 135–146, 1993
Steimle, V., Siegrist, C.-A., Mottet, A., Lisowska-Grospierre, B., and Mach, B. Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA. Science 265: 106–108, 1994
Steimle, V., Durand, B., Emmanuele, B., Zufferey, M., Hadam, M. R., Mach, B., and Reith, W. A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). Genes Dev 9: 1021–1032, 1995
Ting, J. P.-Y. Current concepts in DRA gene regulation. Immunol Res 12: 65–77, 1993
Tsang, S. Y., Nakanishi, M., and Peterlin, B. M. B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene. Proc Natl Acad Sci USA 85: 8598–8602, 1988
Vilen, B. J., Cogswell, J. P., and Ting, J. P.-Y. Stereospecific alignment of the X and Y elements is required for major histocompatibility complex class II DRA promoter function. Mol Cell Biol 11: 2406–2415, 1991
Zhou, H. and Glimcher, L. H. Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency. Immunity 2: 545–553, 1995
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Brown, J.A., He, XF., Westerheide, S.D. et al. Characterization of the expressed CIITA allele in the class II MHC transcriptional mutant RJ2.2.5. Immunogenetics 43, 88–91 (1995). https://doi.org/10.1007/BF00186611
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DOI: https://doi.org/10.1007/BF00186611