Summary
Rat brain cortex slices preincubated with 3H-serotonin were superfused with physiological salt solution (containing citalopram, an inhibitor of serotonin uptake) and the effect of histamine on the electrically (3 Hz) evoked 3H overflow was studied. Histamine decreased the evoked overflow in a concentration-dependent manner. The inhibitory effect of histamine was antagonized by impromidine and burimamide, but was not affected by pheniramine, ranitidine, metitepine and phentolamine. Given alone, impromidine facilitated the evoked overflow, whereas burimamide, pheniramine and ranitidine had no effect. The results suggest that histamine inhibits serotonin release in the rat brain cortex via histamine H3 receptors, which may be located presynaptically.
This is a preview of subscription content, log in via an institution to check access.
References
Arrang J-M, Garbarg M, Schwartz J-C (1983) Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature 302:832–837
Arrang J-M, Garbarg M, Schwartz J-C (1985) Autoregulation of histamine release in brain by presynaptic H3-receptors. Neuroscience 15:553–562
Baumann PA, Waldmeier PC (1981) Further evidence for negative feedback control of serotonin release in the central nervous system. Naunyn-Schmiedeberg's Arch Pharmacol 317:36–43
Göthert M (1982) Modulation of serotonin release in the brain via presynaptic receptors. Trends Pharmacol Sci 3:437–440
Göthert M (1985) Role of autoreceptors in the function of the peripheral and central nervous system. Arzneimittelforschung 35:1909–1916
Grobecker H, Holtz P, Jonsson J (1966) Über die Wirkung des Tyramins auf den isolierten Darm. Naunyn-Schmiedeberg's Arch Pharmacol 255:491–509
Holcslaw TL, Lassiter D (1987) Evidence for presynaptic inhibitory histamine (H2) receptors in the rat hindquarter vasculature. J Cardiovasc Pharmacol 9:651–660
Ishikawa S, Sperelakis N (1987) A novel class (H3) of histamine receptors on perivascular nerve terminals. Nature 327:158 -160
Moret C (1985) Pharmacology of the serotonin autoreceptor. In: Green AR (ed) Neuropharmacology of serotonin, pp. 21–49. Oxford New York Toronto Melbourne: Oxford University Press
Pollard H, Schwartz J-C (1987) Histamine neuronal pathways and their functions. Trends Neurosci 10:86–89
Schlicker E, Classen K, G6thert M (1984) GABAB receptor-mediated inhibition of serotonin release in the rat brain. NaunynSchmiedeberg's Arch Pharmacol 326: 99 -105
Schlicker E, Classen K, G6thert M (1988) Presynaptic serotonin receptors and α-adrenoceptors on central serotoninergic and noradrenergic neurons of normotensive and spontaneously hypertensive rats. J Cardiovasc Pharmacol (in press)
Schwartz J-C, Arrang J-M, Garbarg M (1986) Three classes of histamine receptors in brain. Trends Pharmacol Sci 7:24–28
Subramanian N (1982) Electrically induced release of radiolabeled histamine from rat hippocampal slices: opposing roles for H1-and H2-receptors. Life Sci 31:557–562
van der Werf JF, Bast A, Bijloo GJ, Van der Vliet A, Timmerman H (1987) HA autoreceptor assay with superfused slices of rat brain cortex and electrical stimulation. Eur J Pharmacol 138:199–206
Author information
Authors and Affiliations
Additional information
Send offprint requests to E. Schlicker at the above address
Rights and permissions
About this article
Cite this article
Schlicker, E., Betz, R. & Göthert, M. Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex. Naunyn-Schmiedeberg's Arch Pharmacol 337, 588–590 (1988). https://doi.org/10.1007/BF00182737
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00182737