Skip to main content
Log in

Synovial sarcoma of the extremities

  • Published:
International Orthopaedics Aims and scope Submit manuscript

Summary

From May 1985 to March 1990, 18 cases of Enneking's stage II synovial sarcoma of the extremities were treated by a combination of surgery and CYVADIC chemotherapy with or without radiotherapy. The average follow up was 34.7 months. The estimated 5-year survival rate was 78.4% and the continuously disease-free 5-year survival rate was 44.4%. The results were improved by adequate surgery or chemotherapy when local recurrence or metastases had developed. The combination of surgery and CYVADIC chemotherapy with or without radiotherapy was considered to be an effective method of treating this tumour.

Résumé

Dix-huit synovialo-sarcomes des extrémités de stade II selon Enneking ont été traités entre mai 1985 et mars 1990 par un traitement combiné de chirurgie et de chimiothérapie associant cyclophosphamide — vincristine — adriamycin — dacarbazine (CYVADIC) en ajoutant ou non une radiothérapie. La chirurgie été une excision large (14 cas) ou une amputation (4 cas). La chimiothérapie par CYVADIC a été administrée en 6 cycles chez tous les patients. La radiothérapie (de 50 à 80 Gy, en moyenne de 62 Gy) a été utilisée chez les 14 patients opérés par excision large et chez 1 patient après amputation. Le suivi moyen des malades est de 34,7 mois avec un minimum d'un an. Le taux de survie estimé à 5 ans (méthode de Kaplan-Meier) est de 78,4% et le taux de patients sans signe de maladie est de 44,4%. La survie sans signe de maladie semble améliorée par une chirurgie ou une chimiothérapie adaptée quand il existe une récidive locale ou des métastases. L'association chirurgie et chimiothérapie par CYVADIC avec ou sans radiothérapie, s'avère une méthode efficace de traitement du synovialo-sarcome des extrémités.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Baker AR, Chang AE, Glaststein EG, Rosenber SA (1988) National Cancer Institute experience in the management of high-grade extremity soft tissue sarcoma. In: Ryan IR, Baker LO (eds) Recent concepts in sarcoma. treatment. Dordrecht, Kluwer Academic Publishers, pp 123–129

    Google Scholar 

  2. Benjamin RS, Wernik PH, Baehur NR, (1975) Adriamycin: a new effective agent in the therapy of disseminated sarcomas. Med Pediatr Oncol 1: 63–76

    Google Scholar 

  3. Cadman NL, Soule EH, Kelly PJ (1965) Synovial sarcoma: an analysis of 134 tumors. Cancer 18: 613–627

    Google Scholar 

  4. Cameron HU, Kostuik JP (1965) A long-term follow-up of synovial sarcoma. J Bone Joint Surg [Amn] 18: 613–627

    Google Scholar 

  5. Enneking WF (1986) A system of staging musculoskeletal neoplasm. Clin Orthop 204: 9–24

    PubMed  Google Scholar 

  6. Enzinger FM, Weiss SW (1988) Soft tissue tumors, edn. Mosby, St Louis, pp 659–688

    Google Scholar 

  7. Gerner RE, Moore G (1975) Synovial sarcoma. Ann Surg 181: 22–25

    Google Scholar 

  8. Hampole MK, Jackson BA (1968) Analysis of 25 cases of malignant synovioma. Can Med Assoc J 99: 1025–1029

    Google Scholar 

  9. Kaplan EL, Meier R (1958) Nonparametric estimation from incomplete observation. J Am Stat Assoc 53: 457–481

    Google Scholar 

  10. Mackenzie DH (1966) Synovial sarcoma. A review of 58 cases. Cancer 19: 169

    Google Scholar 

  11. O'Bryan RM, Luce JK, Talley RW (1973) Phase II evaluation of adriamycin in human neoplasia. Cancer 32: 1–8

    Google Scholar 

  12. Pack GT, Ariel IM (1950) Synovial sarcoma (malignant synovioma): a report of 60 cases. Surgery 28: 1047–1084

    Google Scholar 

  13. Russel WO, Cohen J, Enzinger E (1977) A clinical and pathological staging system for soft tissue sarcoma. Cancer 40: 1562

    Google Scholar 

  14. Simon MA (1984) Current concepts review: causes of increased survival of patient with osteosarcoma: current controversies. J Bone Joint Surg 66: 306–310

    CAS  PubMed  Google Scholar 

  15. Suit HD, Mankin HJ, Wilett CG, Gebhardt NC, Wood WC, Skates S (1988) Limited surgery and external irradiation of soft tissue sarcomas. In: Ryan JR, Baker L (eds) Recent Concepts in Sarcoma Treatment. Kluwer Academic Publisher, Dordrecht, pp 94–143

    Google Scholar 

  16. Suit HD, Russel WO, Martin RG (1975) Sarcoma of soft tissue: clinical and histopathological parameters and response to treatment. Cancer 35: 1478

    Google Scholar 

  17. Treuner J, Keim M, Koscielniak E, Burger D, Herbst M, Winkler K, Jurgens H, Ritter D, Niethemmer D (1988) Results of the German soft tissue sarcoma study. In: Ryan JR, Baker LO (eds) Recent Concepts in Sarcoma Treatment. Kluwer Academic Publishers, Dordrecht, pp 164–167

    Google Scholar 

  18. Yap BS, Baker LH, Sinkovics JG, Rivkin SE, Botolmley R, Thigpen T, Burgess MA, Benjamin RS, Bodey GP (1980) Cyclophosphamide, vincristine, adriamycin, and DTIC (CYVADIC) combination chemotherapy for the treatment of advanced sarcomas. Cancer Treat Rep 64: 93–98

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, SY., Jeon, DG. & Kim, SS. Synovial sarcoma of the extremities. International Orthopaedics 17, 293–296 (1993). https://doi.org/10.1007/BF00181702

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00181702

Keywords

Navigation