Abstract
Two cases of Merkel cell carcinoma, a neuroendocrine neoplasia of the skin, investigated with iodine-131 metaiodobenzylguanidine (131i-mIBG) scintigraphy, are reported. Uptake in the tumor was evident only in 1 case. The possible diagnostic and therapeutic role of 131I-mIBG in patients with this rare neoplasm is discussed.
Similar content being viewed by others
References
Adolph J, Kimmig B (1989) Diagnostik und Therapie neuroektodermaler Tumore. Radiologe 29:32–42
Bomanji J, Levison DA, Flatman WD, Horne T, Bouloux PM, Ross G, Britton KE, Besser GM (1987) Uptake of iodine-123 MIBG by pheochromocytomas, paragangliomas, and neuroblastomas: a histopathological comparison. J Nucl Med 28:973–978
Brown P, Pinkston JA, Blackmon JA, McMahon JM (1987) Merkel cell carcinoma. Report of a case and possible role for adjuvant radiotherapy. J Surg Oncol 34:136–141
Davis MP, Miller EM, Rau RC, Johnson OE, Naille RA, Crnkovich MJ (1990) The use of VIP16 and crisplatin in the treatment of Merkel cell carcinoma. J Dermatol Surg Oncol 16:276–278
Dolezal RF, Cohen M, Taxy JB (1988) Merkel tumor of the lower lip: a case report and updated review of the literature work performed at the University of Illinois. J Surg Oncol 37:123–127
Fielding SL, Flower MA, Ackery DM, Kemshead JT, Lashford LS, Lewis I (1991) Dosimetry of iodine 131 metaiodobenzylguanidine for treatment of resistant neuroblastoma: results of a UK study. Eur J Nucl Med 18:308–316
Hanke WC, Conner AC, Temofeew RK, Lingeman RE (1989) Merkel cell carcinoma. Arch Dermatol 125:1096–1100
Hoefnagel CA (1991) Radionuclide therapy revisited. Eur J Nucl Med 18:408–431
Mercer D, Brander P, Liddell K (1990) Merkel cell carcinoma: the clinical course. Ann Plast Surg 25:136–141
Moyes JSE, McCready VR, Fullbrook AC (1989) Appendix E: drugs which interfere with mIBG studies. In: Moyes JSE, McCready VR, Fullbrook AC (eds) Neuroblastoma — mIBG in its management and diagnosis. Springer, Berlin Heidelberg New York
Morrison WH, Peters LJ, Silva EG, Wendt CD, Ang KK, Goepfert H (1990) The essential role of radiation therapy in securing loco-regional control of Merkel cell carcinoma. Int J Radiat Oncol Biol Phys 19:583–591
Nakajo M, Shapiro B, Copp J, Kalff V, Gross MD, Sisson JC, Beierwaltes WH (1983) The normal and abnormal distribution of the adrenomedullary imaging agent m(I-131) iodobenzylguanidine (I-131-MIGB) in man: evaluation by scintigraphy. J Nucl Med 24:672–682
Sibley RK, Rosai J, Foucar E, Delmer LP, Bosl G (1980) Neuroendocrine (Merkel cell) carcinoma of the skin: a histopathological and ultrastructural study of two cases. Am J Surg Pathol 4:211–221
Sisson JC, Shapiro B, Beierwaltes WH, Glowniak JV, Nakajo M, Mangner TJ, Carey JE, Swanson DP, Copp JE, Satterlee WG, Wieland DM (1984) Radiopharmaceutical treatment of malignant pheochromocytoma. J Nucl Med 24:197–206
Sisson JC, Hutchinson RJ, Carey JE, Shapiro B, Johnson JW, Mallette SA, Wieland DM (1988) Toxicity from treatment of neuroblastoma with 131I meta-iodobenzyl-guanidine. Eur J Nucl Med 14:337–340
Taxy JB, Ettinger DS, Wharam MD (1980) Primary small cell carcinoma of the skin. Cancer 46:2308–2311
Troncone L, Rufni V, Montemaggi P, Danza FM, Lasorella A, Mastrangelo R (1990) The diagnostic and therapeutic utility of radioiodinated metaiodo-benzylguanidine (MIBG). Eur J Nucl Med 16:325–335
Von Moll L, McEwan AJ, Shapiro B, Sisson JC, Gross MD, Lloyd R, Beals E, Beierwaltes WH, Thompson NW (1987) Iodine-131 MIBG scintigraphy of neuroendocrine tumors other than pheocromocytoma and neuroblastoma. J Nucl Med 28:979–988
Author information
Authors and Affiliations
Additional information
Offprint requests to: A. Castagnoli
Rights and permissions
About this article
Cite this article
Castagnoli, A., Biti, G., De Cristofaro, M.T.R. et al. Merkel cell carcinoma and iodine-131 metaiodobenzylguanidine scan. Eur J Nucl Med 19, 913–916 (1992). https://doi.org/10.1007/BF00168169
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00168169