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Steroid hormone receptors in human meningiomas, gliomas and brain metastases

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Summary

Progestin, estrogen, androgen, glucocorticoid as well as mineralocorticoid receptors (PR, ER, AR, GR and MR, respectively) were all evaluated with specific synthetic radioligands (biochemical assays) in 25 meningiomas, 9 gliomas and 4 brain metastases. In meningiomas the main steroid hormone receptors appeared to be the progestin receptor, present in 24/25 cases (mean level: 7 105 fmol/ gT) and the androgen receptor, present in 23/25 cases (mean level: 2 265 fmol/ gT). Progestin receptor levels were found to be significantly lower in meningiomas of the fibroblastic subtype whereas none of the steroid hormone receptors were detected in the anaplastic case. On the other hand, glucocorticoid receptor levels were related to the preoperative glucocorticoid therapy. In gliomas only estrogen receptors (2/9 cases) and especially androgen receptors (8/9 cases) were noticeable: the latter seemed to be related to the histological types and to the sex of patients. No receptors were found in any of the four studied metastases, including one from breast cancer. The biochemical characterization of the receptors as well as their relevance to tumor biology and to the physiology of the normal tissues where tumors arise, were discussed, and biochemical data were compared with those previously reported.

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Authors and Affiliations

  1. Departments of Neurology, La Salpétrière Hospital, La Pitié-Salpé-trière Faculty of Medicine, Paris, France

    Michel Poisson, Bertrand F. Pertuiset & André Buge

  2. Departments of Neuropathology, La Salpétrière Hospital, La Pitié-Salpé-trière Faculty of Medicine, Paris, France

    Bertrand F. Pertuiset & Jean-Jacques Hauw

  3. Departments of Neurosurgery, La Salpétrière Hospital, La Pitié-Salpé-trière Faculty of Medicine, Paris, France

    Jacques Philippon

  4. Roussel-Uclaf Research Centre, Romainville, France

    Martine Moguilewsky & Daniel Philibert

Authors
  1. Michel Poisson
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  2. Bertrand F. Pertuiset
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  3. Jean-Jacques Hauw
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  4. Jacques Philippon
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  5. André Buge
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  6. Martine Moguilewsky
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  7. Daniel Philibert
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Address for reprints: M. Poisson, Clinique Neurologique, Hôpital de la Salpetriere, 75651 Paris Cedex 13, France

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Poisson, M., Pertuiset, B.F., Hauw, JJ. et al. Steroid hormone receptors in human meningiomas, gliomas and brain metastases. J Neuro-Oncol 1, 179–189 (1983). https://doi.org/10.1007/BF00165601

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