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Sexual transmission of hepatitis C virus infection

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Abstract

The role of sexual transmission in the diffusion of HCV infection, was studied through the seroprevalence of anti-HCV antibodies in the heterosexual habitual partners of 83 anti-HCV positive subjects. The index cases were represented by 10 dialysed subjects, 31 patients with chronic liver disease and 42 healthy carriers. Seroprevalence of anti-HCV positivity reported in partners was 8.43%, with a higher rate in cohabitants of patients with chronic liver disease (16.12% vs 4.76% of carriers); no case was found among partners of dialysed subjects. Laboratory and ultrasonograph signs of chronic hepatitis were reported in 3 cases (3.61%). Control on 70% of the cohabitants' relatives, was negative for HCV infections. These data suggest a possible sexual transmission of HCV infection, even if its prevalence resulted modest, undoubtedly lower than in other disease sexually transmitted.

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References

  1. Choo Q-L, Kuo G, Houghton M, et al. Isolation of a cDNA clone derived from a blood-borne non A, nonB viral hepatitis genome. Science 1989; 244: 359–362.

    Google Scholar 

  2. Houghton M, Weiner A, Han J. Molecular biology of hepatitis C virus: Implication for diagnosis, development and control of viral disease. Hepatology 1991; 14: 381–388.

    Google Scholar 

  3. Alter MI. Inapparent transmission of hepatitis C: Footprints in the sand. Hepatology 1991; 14: 389–391.

    Google Scholar 

  4. Alter MJ, Hadler SC, Judson FN, et al. Risk factors for acute non A non B hepatitis in the United States and association with C virus infection. JAMA 1990; 264:2231–2235.

    Google Scholar 

  5. Tedder RS, Gilson R, Briggs M, et al. Hepatitis C virus: Evidence for sexual transmission. Br Med J 1991; 302: 1299–1302.

    Google Scholar 

  6. Cilla G, Perez Trallero E, Iturriza M, et al. Possibility of heterosexual transmission of hepatitis C virus. Eur J Clin Microbiol Infect Dis 1991; 10: 533–534.

    Google Scholar 

  7. Tor J, Libre JM, Corbonell M, et al. Sexual transmission of hepatitis C virus and its relation with hepatitis B virus and HIV. Br Med J 1990; 301: 1130–1133.

    Google Scholar 

  8. Hess G, Massing A, Rossel S, et al. Hepatitis C virus and sexual transmission. Lancet 1989: 987.

  9. Osmond DM, Padian NS, Sheppard HW, et al. Risk factors for hepatitis C virus seropositivity in hetero-sexuals couples. JAMA 1993; 269: 361–365.

    Google Scholar 

  10. Eyster ME, Alter MJ, Aledort LM, et al. Heterosexual cotransmission of hepatitis C virus (HCV) and human immunodeficiency virus (HIV). Ann Int Med 1991; 115: 764–768.

    Google Scholar 

  11. Benamouzig R, Ezratty V, Chaussade S. Risk for hepatitis through sexual contact. Ann Int Med 1990; 113: 638.

    Google Scholar 

  12. Lissen E, Alter MJ, Abed MA, et al. Hepatitis C virus infection among sexually promiscous groups and the heterosexual partners of hepatitis C virus infected index cases. Eur J Clin Microbiol Infect Dis 1993; 11, 827–831.

    Google Scholar 

  13. Simmonds P, Holmes EC, Cha TA, et al. Classification of hepatitis C virus into six major genotypes and a series of subtypes by philogenetic analysis of the NS5 region. J Gen Viral 1993; 74: 2391–2399.

    Google Scholar 

  14. Brettler DB, Mnnucci PM, Gringeri A, et al. The low risk of hepatitis C virus transmission among sexual partners of hepatitis C infected hemophilic males: An international, multicenter study. Blood 1992; 80: 540–543.

    Google Scholar 

  15. Piazza M. Epatite virale acuta e cronica. Milano: Ghedini 1990: 37–38.

    Google Scholar 

  16. Chiaramonte M, Stroffolini T. Aspetti epiderniologici della Infezione da virus dell'epatite C. Rapporti Istisan 1990: 11–45.

  17. Stary A, Kopp W, Hofman M, et al. Seroepidemiologic study of hepatitis C virus in sexually transmitted disease risk groups. Sex Transm Dis 1992; 19: 252–258.

    Google Scholar 

  18. Kao JM, Chen PJ, Wang PM, et al. Intrafamilial transmission hepatitis C virus: The important role of infection between spouses. Journal Infect Dis 1992; 166: 900–903.

    Google Scholar 

  19. Mast EE, Darrow WW, Witte J, et al. Hepatitis C virus infection among prostitutes: Evidences for sexual transmission and protective efficacy of condom. Proc 3rd Inter Symp on HCV, Strasbourg 1991: E 52.

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Scotto, G., Savastano, A.M., Fazio, V. et al. Sexual transmission of hepatitis C virus infection. Eur J Epidemiol 12, 241–244 (1996). https://doi.org/10.1007/BF00145412

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