Abstract
Solubilities and transfer chemical potentials of carboplatin, cisplatin, iproplatin, and several related platinum complexes have been determined in methanol-water mixtures. the range of solvation behaviour is discussed in relation to possible oral administration of complexes of this type.
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Alshehri S, Burgess J, Darcey KA, Patel MS. 1994 Solvation of ethylmaltol and of its iron(III) complex. Transition Met Chem 19, 119–122.
Barnard CFJ, Cleare MJ, Hydes PC. 1986 Second generation anticancer platinum compounds. Chem Brit 22, 1001–1004.
Blandamer MJ, Burgess J. 1988 Solvation of transition metal complexes: thermochemical approaches. Transition Met Chem 13, 1–18.
Blandamer MJ, Burgess J, Duce PP, Duffield AJ, Hamshere SJ. 1981 Initial state and transition state solvation in substitution at the square-planar complexes [PtCl4]2− and [Pd(Et4dien)Cl]+. Transition Met Chem 6, 368–371.
Burgess J. 1993 Transition metals in diagnosis and therapy. Transition Met Chem 18, 439–448.
Burgess J, Abu-Gharib EA. 1984 Solubilities of salts of co- balt(III), chromium(III), and iron(II) complexes in aqueous methanol; transfer chemical potentials of anions. Transition Met Chem 9, 234–236.
Burgess J, Drasdo DN. 1993 Solubilities of calcium salts of dicarboxylic acids in methanol-water mixtures; transfer chem- ical potentials of dicarboxylate anions Polyhedron 12, 2905–2911.
Burgess J, Patel MS. 1990 Solvation of tris-maltolato-alumin- ium(III) and related complexes in methanol-water mixtures. Inorg Chim Acta 170, 241–243.
Burgess J, Radulovic S, Sanchez F. 1987 Solvatochromism and solvation of ternary iron-diimine-cyanide complexes. Transi- tion Met Chem 12, 529–536.
Burgess J, Drasdo DN, Patel MS. 1994 Solubilities and solvation of aluminum(III), iron(III), and indium(III) 8-hydroxyquino- linates in methanol/water mixtures. J Pharm Sci 83, 54–57.
Canovese L, Cattalini L, Chessa G, Tobe ML. 1988 Kinetics of the displacement of cyclobutane-1,1′-dicarboxylate from diammine-(cyclobutane-1,1′-dicarboxylato)platinum(II) in aqueous solution. J Chem Soc Dalton Trans, 2135–2140.
Griffin WC. 1954 Calculation of HLB values for non-ionic surfactants. J Soc Cosmet Chem 5, 249–256.
Hansch C, Leo A. 1979 Substitution Constants for Correlation Analysis in Chemistry and Biology. New York: Wiley; 49–54.
Hardaway LA, Yalkowsky SH. 1991 Cosolvent effects on diuron solubility. J Pharm Sci 80, 197–198.
Kelland LR. 1993 New platinum antitumor complexes. Crit Rev Oncol Hematol 15, 191–219.
McKeage MJ, Boxall FE, Jones M, Harrap KR. 1994 Lack of neurotoxicity of oral bisacetatoamminedichlorocyclohexyl- amine-platinum(IV) in comparison to cisplatin and carboplatin in the rat. Cancer Res 54, 629–631.
Morikawa K, Honda M, Endoh K, et al. 1991 Synthesis, antitumor activity, and nephrotoxicity of the optical isomers of 2-amino-methylpyrrolidine(1,1′-cyclobutanedicarboxylato)- platinum(II). J Pharm Sci 80, 837–842.
Pujol M, Part J, Trillas M, Domenech X. 1993 Stability of aqueous carboplatin solutions under illumination. Monatsh Chem 124, 1077–1081.
Reedijk J, Fichtinger-Schepman AMJ, van Oosterom AT, van de Putte P. 1987 Platinum amine coordination compounds as anti-tumor drugs. Molecular aspects of the mechanism of action. Struct Bonding 67, 53–89.
Rekker RF, Mannhold R. Calculation of Drug Lipophilicity, Weinheim: VCH.
Shkadova AI. 1969 Solubility of sulfanilamide compounds in ethanol-water mixtures. Farm Zh (Kiev) 24, 39–41.
Stein WD. 1986 Transport and Diffusion across Cell Membranes. Orlando, FL: Academic Press; 103–107.
Van der Veer JL, Reedijk J. 1988 Investigating antitumour drug mechanisms. Chem Brit 24, 775–780.
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Burgess, J., Drasdo, D.N. & Patel, M.S. Solvation of platinum anti-cancer drugs in methanol-water mixtures. Biometals 8, 137–141 (1995). https://doi.org/10.1007/BF00142013
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DOI: https://doi.org/10.1007/BF00142013