Abstract
A preferential looking technique was used to measure visual acuity in human infants under one year of age who experienced monocular visual form deprivation. Of the 14 cases reviewed, 9 infants had monocular occlusion as therapy for esotropia; 3 infants had unilateral opacities of the ocular media; and 2 infants had unilateral eyelid closure from infection or burns. Despite differences in exact mode of deprivation, the effects on visual acuity were similar. There was a reduction in visual acuity in the deprived eye and a simultaneous increase in acuity of the non-deprived eye. These effects of monocular deprivation were not permanent. Recovery occurred with reverse deprivation or by simple cessation of the deprivation.
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Arden GB and Barnard WM (1979) Effect of occlusion on the visual evoked response in amblyopia. Trans Ophthal Soc UK 99:419–426
Atkinson J and Braddick O (1979) Assessment of vision in infants. Trans Ophthal Soc UK 99:338–343
Awaya S, Miyake Y, Imaizumi Y, Shiose Y, Kanda T and Komuro K (1973) Amblyopia in man, suggestive of stimulus deprivation amblyopia. Jap J Ophthal 17:69–82
Awaya S, Sugawara J and Miyake S (1979) Observations in patients with occlusion amblyopia. Trans Ophthal Soc UK 99:447–454
Calhoun JH (1977) Cutting-aspiration instruments. Int Ophthal Clinics 17:103–118
Cook RG and Glasscock RE (1951) Refractive and ocular findings in the newborn. Amer J Ophthal 34:1407–1413
Crawford MLJ (1978) Visual deprivation syndrome. Ophthalmology 85:465–477
Crewther DP, Crewther SG and Mitchell DE (1981) The efficacy of brief periods of reverse occlusion in promoting recovery from the physiological effects of monocular deprivation in kittens. Invest Ophthal Vis Sci 21:357–362
Dobson V and Teller DY (1978) Visual acuity in human infants: a review and comparison of behavioral and electrophysiological studies. Vision Res 18:1469–1483
Duke-Elder S and Abrams D (1970) Ophthalmic Optics and Refraction. In: (S. Duke-Elder, Ed.) System of Ophthalmology, Vol. 5. London, Kimpton, pp 224–226
Enoch JM and Rabinowicz IM (1976) Early surgery and visual correction of an infant born with unilateral eye lens opacity. Docum Ophthal 41:371–382
Enoch JM, Rabinowicz IM and Campos EC (1979) Post surgical contact lens correction of infants with sensory deprivation amblyopia associated with unilateral congenital cataract. J Jpn CL Soc 21:95–104
Giffin F and Mitchell DE (1978) The rate of recovery of vision after early monocular deprivation in kittens. J Physiol 74:511–537
Gwiazda J, Brill S, Mohindra I and Held R (1978) Infant visual acuity and its meridional variation. Vision Res 18:1557–1564
Gwiazda J, Wolfe JM, Brill S, Mohindra I and Held R (1980-A) Quick assessment of preferential looking acuity in infants. Amer J Optom Physiol Optics 57:420–427
Gwiazda J, Brill S, Mohindra I and Held R (1980-B) Preferential looking acuity in infants from two to fifty-eight weeks of age. Amer J Optom Physiol Optics 57:428–432
Hartwig H, Haver U, Kanther A and Kaufmann H (1976) Zur Frage der Deprivationsamblyopie. Klin Mbl Augenheilk 168:414–418
Hubel DH and Wiesel TN (1977) Functional architecture of macaque monkey visual cortex. Proc Roy Soc Lond B 198:1–59
Jacobson SG, Mohindra I and Held R (1981-A) Development of visual acuity in infants with congenital cataracts. Brit J Ophthal 65:727–735
Jacobson SG, Mohindra I and Held R (1981-B) Age of onset of amblyopia in infants with esotropia. Docum Ophthal Proc Ser 30:210–216
Jacobson SG, Mohindra I and Held R (1982) Visual acuity of infants with ocular diseases. Amer J Ophthal 93:198–209
Lehmkuhle S, Kratz KE, Mangel SC and Sherman SM (1980) Effects of early monocular lid suture on spatial and temporal sensitivity of neurons in dorsal lateral geniculate nucleus of the cat. J Neurophysiol 43:542–556
Lund RD (1978) Environmental influences on visual responsiveness. In: (R.D. Lund, Ed.) Development and Plasticity of the Brain. New York, Oxford University Press, pp 253–284
Mohindra I and Held R (1981) Refractions in humans from birth to five years. Docum Ophthal Proc Ser 28:19–27
Mohindra I, Held R and Jacobson SG (1981) Interocular interaction and superacuity in human infants with monocular visual deprivation. Invest Ophthal Vis Sci 20:119
Mohindra I, Jacobson SG, Thomas J and Held R (1979) Development of amblyopia in infants. Trans Ophthal Soc UK 99:344–346
Mohindra I, Jacobson SG and Held R (1983) Binocular visual form deprivation. Docum Ophthal 55:237–249
Movshon JA (1976) Reversal of the physiological effects of monocular deprivation in the kitten's visual cortex. J Physiol 261:125–174
Odom JV, Hoyt CS and Marg E (1981) Effect of natural deprivation and unilateral eye patching on visual acuity of infants and children: evoked potential measurements. Arch Ophthal 99:1412–1416
Olson CR and Freeman RD (1978) Monocular deprivation and recovery during sensitive period in kittens. J Neurophysiol 41:65–74
Olson CR and Freeman RD (1980) Cumulative effect of brief daily periods of monocular vision on kitten striate cortex. Exp Brain Res 38:53–56
Schepens CL and Constable IJ (1977) Open sky vitrectomy: operative technique and instrumentation; In: (H.M. Freeman, T. Hirose, C.L. Schepens, eds.) Vitreous Surgery and Advances in Fundus Diagnosis and Treatment. New York, Appleton-Century-Crofts, pp 465–477
Thomas J, Mohindra I and Held R (1979) Strabismic amblyopia in infants. Amer J Optom Physiol Optics 56:197–201
Vaegan, Arden GB and Fells P (1981) Amblyopia: some possible relations between experimental models and clinical experience. In: (D. Taylor and K. Wybar, eds.) Paediatric Ophthalmology. New York, Decker
Vaegan and Taylor D (1979) Critical period for deprivation amblyopia in children. Trans Ophthal Soc UK 99:432–439
von Noorden GK (1981) New clinical aspects of stimulus deprivation amblyopia. Amer J Ophthal 92:416–421
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Jacobson, S.G., Mohindra, I. & Held, R. Monocular visual form deprivation in human infants. Doc Ophthalmol 55, 199–211 (1983). https://doi.org/10.1007/BF00140809
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DOI: https://doi.org/10.1007/BF00140809