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The effect of culture conditions on the production of erythromycin by Saccharopolyspora erythraea in batch culture

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Summary

Saccharopolyspora erythraea growth is inhibited when grown at a low constant dissolved oxygen tension (DOT) of 10% air saturation. However, the specific erythromycin production is virtually identical to that of a culture where the DOT did not fall below 65%. In addition, at constant DOT (10%) a stirrer speed of 750 rpm in a 7 litre causes mechanical damage to the mycelia in comparison with result at 500 rpm.

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Authors and Affiliations

  1. The Advanced Centre for Biochemical Engineering, Department of Chemical and Biochemical Engineering, University College London, WC1E 7JE, Torrington Place, London, UK

    S. M. Heydarian, M. D. Lilly & A. P. Ison

Authors
  1. S. M. Heydarian
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  2. M. D. Lilly
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  3. A. P. Ison
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Heydarian, S.M., Lilly, M.D. & Ison, A.P. The effect of culture conditions on the production of erythromycin by Saccharopolyspora erythraea in batch culture. Biotechnol Lett 18, 1181–1186 (1996). https://doi.org/10.1007/BF00128589

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  • DOI: https://doi.org/10.1007/BF00128589

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